{"id":"W2107416433","doi":"10.1371/journal.pgen.1003930","title":"Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":258,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Biology; DNA mismatch repair; Trinucleotide repeat expansion; MSH2; Genetics; MLH1; Huntingtin; Locus (genetics); Gene; DNA repair; Mutant; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003362808,0.0004095097,0.0003217367,0.0005956903,0.0001874777,0.0003481109,0.0003233748,0.0004640617,0.001194203],"category_scores_gemma":[0.0001128538,0.0002529272,0.000289565,0.0002901111,0.0002741602,0.0002162791,0.0002622476,0.0007278888,0.0001687752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003197768,"about_ca_system_score_gemma":0.0001970082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005913345,"about_ca_topic_score_gemma":0.001819721,"domain_scores_codex":[0.9998318,0.00002485158,0.00001258519,0.00004908207,0.00004942497,0.00003217309],"domain_scores_gemma":[0.9998825,0.0000237088,0.00004509858,0.000008898935,0.000009107622,0.00003082656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001306066,0.00003452597,0.0002356629,0.0000233511,0.000009745891,0.0000307395,0.00001192965,0.00005061126,0.9974561,0.0001207765,0.00002107489,0.001874974],"study_design_scores_gemma":[0.00009200366,0.0008941963,0.0161376,0.00001412614,0.0001225098,0.0004635246,0.0000549312,0.001373664,0.977329,0.0001768858,0.003324802,0.00001676713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868029,0.002600502,0.007656028,0.0002713494,0.00003862459,0.00008649884,0.0009227599,0.0002532412,0.001368089],"genre_scores_gemma":[0.9855859,0.002833394,0.005698999,0.0001966103,0.00002345658,0.00009216469,0.0008613981,0.00009019384,0.004617951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194203,"threshold_uncertainty_score":0.003995001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04473891067345155,"score_gpt":0.2343420771633968,"score_spread":0.1896031664899452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}