{"id":"W2107422681","doi":"10.1111/jnc.13389","title":"<i>In vivo</i> and <i>ex vivo</i> regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator‐activated receptor alpha (Pparα) at the blood–brain barrier","year":2015,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Abcg2; Blood–brain barrier; Clofibrate; In vivo; Peroxisome proliferator-activated receptor; Ex vivo; Receptor; Chemistry; Biology; Pharmacology; Endocrinology; Cell biology; Internal medicine; Transporter; ATP-binding cassette transporter; Biochemistry; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003320236,0.000520062,0.000286619,0.000246413,0.0001926506,0.0005772559,0.0002369784,0.0003664991,0.002695472],"category_scores_gemma":[0.0001657149,0.00022653,0.0004866952,0.0002849656,0.0004100781,0.0004363733,0.0001542227,0.001045917,0.0008732574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004830615,"about_ca_system_score_gemma":0.000229991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005611,"about_ca_topic_score_gemma":0.001253971,"domain_scores_codex":[0.9995665,0.0001013399,0.00003816796,0.0001155708,0.00008928647,0.00008919183],"domain_scores_gemma":[0.9997804,0.00003894995,0.00007580024,0.00004186986,0.00003687954,0.00002622003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000277559,0.00004701397,0.00007653678,0.00005773151,0.000008022595,0.00003295616,0.00000909688,0.00003527327,0.9986498,0.0001001457,0.000180567,0.0005254833],"study_design_scores_gemma":[0.00002077657,0.0002748589,0.00193264,0.000005283396,0.00001857533,0.0002252169,0.00001915052,0.00042191,0.9946267,0.00003913392,0.002410165,0.000005599997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968361,0.004135609,0.01619848,0.001043316,0.0002599948,0.0001070065,0.003246745,0.0005020382,0.006145956],"genre_scores_gemma":[0.963308,0.003586207,0.01473262,0.0005144336,0.0001223187,0.000333311,0.005622197,0.0002340245,0.01154706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002695472,"threshold_uncertainty_score":0.009017229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007319975773835714,"score_gpt":0.2283318800627299,"score_spread":0.2210119042888941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}