{"id":"W2107445027","doi":"10.1242/dev.127.18.3941","title":"Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression","year":2000,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":428,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Biology; Embryonic stem cell; Vasculogenesis; Embryogenesis; Cell biology; Embryonic heart; Vascular endothelial growth factor; Vascular endothelial growth factor A; Endogeny; Heart development; Mutant; Embryo; Locus (genetics); Gene; Cancer research; Endocrinology; VEGF receptors; Genetics; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001672583,0.0002658198,0.0002061836,0.00009398388,0.0001346523,0.00003905824,0.0002641737,0.0001620785,0.0007056594],"category_scores_gemma":[0.00004925543,0.0002508897,0.00006504757,0.0001709579,0.0000423913,0.000009381138,0.0001942046,0.0001335516,0.0002096165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298537,"about_ca_system_score_gemma":0.0004503818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005126406,"about_ca_topic_score_gemma":0.00009053427,"domain_scores_codex":[0.9980558,0.00008890216,0.0003277904,0.0005763636,0.0004243022,0.000526836],"domain_scores_gemma":[0.9993798,0.00002004555,0.0000318038,0.0003013672,0.00006884111,0.000198198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001673035,0.000347357,0.01193011,0.00004528817,0.00007982085,0.00002378097,0.0004926036,0.000005766194,0.9347847,9.504636e-7,0.001209649,0.05091268],"study_design_scores_gemma":[0.0008348728,0.00004888322,0.03574231,0.00003333486,0.000002591064,0.000006799381,0.00001782124,0.00002010276,0.8563148,0.00000406265,0.1066438,0.0003305989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978598,0.0009748665,0.0001780829,0.00002576895,0.0000276391,0.0003739863,0.00004261408,0.00002195581,0.0004952493],"genre_scores_gemma":[0.9927861,0.0003385628,0.003061462,0.000161525,0.00004501344,0.0001575882,0.0003820851,0.0000402663,0.00302738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1054341,"threshold_uncertainty_score":0.9999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084267803311786,"score_gpt":0.2520969883869906,"score_spread":0.2412543103538727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}