{"id":"W2107445027","doi":"10.1242/dev.127.18.3941","title":"Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression","year":2000,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":428,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Biology; Embryonic stem cell; Vasculogenesis; Embryogenesis; Cell biology; Embryonic heart; Vascular endothelial growth factor; Vascular endothelial growth factor A; Endogeny; Heart development; Mutant; Embryo; Locus (genetics); Gene; Cancer research; Endocrinology; VEGF receptors; Genetics; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120136,0.0003979154,0.0002471252,0.0003004599,0.0001336562,0.0004176471,0.000217638,0.0003069484,0.001123106],"category_scores_gemma":[0.0002693022,0.000256171,0.0001526133,0.0001142925,0.000432475,0.00017049,0.0003961214,0.0005786008,0.0004052252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002788654,"about_ca_system_score_gemma":0.000237798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006069567,"about_ca_topic_score_gemma":0.0006989547,"domain_scores_codex":[0.9997669,0.00002687219,0.00003333479,0.00005319127,0.00007960822,0.00004002968],"domain_scores_gemma":[0.9996184,0.00007730818,0.000146019,0.00003605403,0.00001860549,0.0001036368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003973401,0.000007337377,0.0002079201,0.00001035365,0.000002468877,0.0001324608,0.000008102989,0.00003449156,0.9989293,0.00009875314,0.00001824225,0.00051079],"study_design_scores_gemma":[0.00002282734,0.0002083008,0.01092255,0.00001021829,0.00001778148,0.001664572,0.00003030749,0.000645872,0.9835318,0.0001093838,0.002828519,0.000007818626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926242,0.000848331,0.004499022,0.00009611029,0.00002472024,0.00001352744,0.0004545548,0.0002241006,0.00121532],"genre_scores_gemma":[0.9950668,0.0005250655,0.002204988,0.00003125415,0.000006579017,0.00001993324,0.0003622802,0.00005128889,0.001731828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001123106,"threshold_uncertainty_score":0.003757119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084267803311786,"score_gpt":0.2520969883869906,"score_spread":0.2412543103538727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}