{"id":"W2107481002","doi":"10.2337/db06-0823","title":"Ceramide- and Oxidant-Induced Insulin Resistance Involve Loss of Insulin-Dependent Rac-Activation and Actin Remodeling in Muscle Cells","year":2007,"lang":"en","type":"article","venue":"Diabetes","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Natural Science Foundation of China","keywords":"GLUT4; Protein kinase B; Ceramide; Insulin receptor; Biology; Insulin resistance; Glucose uptake; Cell biology; Phosphorylation; Actin remodeling; Actin cytoskeleton; Glucose transporter; Insulin; Internal medicine; Chemistry; Endocrinology; Biochemistry; Cell; Cytoskeleton; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005576375,0.0001615134,0.0002395347,0.00008988054,0.00004307557,0.00002063072,0.00009305609,0.0001759816,0.000004477181],"category_scores_gemma":[0.0001249351,0.0001669146,0.00003335243,0.00012201,0.00006777543,0.0000166377,0.00007357846,0.0001235995,6.471562e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001934828,"about_ca_system_score_gemma":0.00004052294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004663406,"about_ca_topic_score_gemma":0.0001361797,"domain_scores_codex":[0.9987983,0.00005395881,0.0003419599,0.0003674013,0.0001413613,0.0002970436],"domain_scores_gemma":[0.999395,0.00005095034,0.0001590636,0.0002268409,0.00008896539,0.00007918989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006901428,0.00004692088,0.004351866,0.00008301845,0.00001617055,8.235389e-7,0.0002192201,0.00001783985,0.9372769,0.00002877163,0.00001607588,0.05787338],"study_design_scores_gemma":[0.0008658607,0.0000536085,0.0254233,0.00007119917,0.00001080496,1.457855e-7,0.0002262516,0.00007719969,0.9699464,0.0002913693,0.002842745,0.0001910695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568128,0.04262155,0.0001120847,0.00001853187,0.00009842835,0.0001664517,0.00001409145,0.000007506157,0.0001485359],"genre_scores_gemma":[0.9893229,0.00978924,0.000516851,0.0001722749,0.0001154765,0.000007129666,0.0000234877,0.0000221669,0.00003047171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05768231,"threshold_uncertainty_score":0.6806582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109696446910432,"score_gpt":0.235309114439969,"score_spread":0.2242121499708647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}