{"id":"W2107481002","doi":"10.2337/db06-0823","title":"Ceramide- and Oxidant-Induced Insulin Resistance Involve Loss of Insulin-Dependent Rac-Activation and Actin Remodeling in Muscle Cells","year":2007,"lang":"en","type":"article","venue":"Diabetes","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Natural Science Foundation of China","keywords":"GLUT4; Protein kinase B; Ceramide; Insulin receptor; Biology; Insulin resistance; Glucose uptake; Cell biology; Phosphorylation; Actin remodeling; Actin cytoskeleton; Glucose transporter; Insulin; Internal medicine; Chemistry; Endocrinology; Biochemistry; Cell; Cytoskeleton; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019186,0.0003828851,0.0004001283,0.0001944142,0.0001987612,0.0002850191,0.0002280892,0.0003686951,0.001235348],"category_scores_gemma":[0.0001000285,0.0001809739,0.0004986107,0.000139353,0.0002372348,0.0003055461,0.0002278106,0.000635033,0.0003765849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003010876,"about_ca_system_score_gemma":0.0001907439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003064049,"about_ca_topic_score_gemma":0.0003921169,"domain_scores_codex":[0.9998061,0.00003348771,0.00002655844,0.0000368212,0.00005585398,0.00004107208],"domain_scores_gemma":[0.9999166,0.000006360497,0.00002529735,0.00001424073,0.00001224799,0.00002523771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002728809,0.0000379166,0.0001599965,0.0000429703,0.000008487329,0.00008503488,0.000009492729,0.000022143,0.9981164,0.00008447402,0.00001922968,0.001141096],"study_design_scores_gemma":[0.00003806707,0.0003362545,0.01120108,0.000007655444,0.00001689388,0.0004455171,0.00002628937,0.0003661689,0.9862,0.00007993926,0.001275903,0.000006156534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991618,0.003454366,0.002468437,0.0001424675,0.00004890155,0.0000579852,0.0003282427,0.00006862744,0.001812841],"genre_scores_gemma":[0.992973,0.00176854,0.00195268,0.0001096828,0.00001731028,0.00009538713,0.0005140555,0.00001770386,0.002551614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235348,"threshold_uncertainty_score":0.004132628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109696446910432,"score_gpt":0.235309114439969,"score_spread":0.2242121499708647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}