{"id":"W2107505408","doi":"10.1158/1078-0432.ccr-10-0054","title":"Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers","year":2010,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute","keywords":"Medicine; Radiation therapy; Gastroenterology; Neutropenia; Asymptomatic; Toxicity; Internal medicine; Cancer; Mesothelioma; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00155922,0.0001381874,0.0002698702,0.0001218201,0.00008363528,0.00001991657,0.000238364,0.0001211242,0.00006892143],"category_scores_gemma":[0.0002659728,0.0001159794,0.00002953979,0.0004354775,0.0004059117,0.00001255877,0.0001087164,0.0008156576,0.000001054564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000791925,"about_ca_system_score_gemma":0.0005427942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008176481,"about_ca_topic_score_gemma":0.01668595,"domain_scores_codex":[0.9976855,0.0004755154,0.0003910523,0.0005430876,0.0005075696,0.0003972549],"domain_scores_gemma":[0.9986882,0.0001259206,0.0001019399,0.0004365404,0.0004849517,0.0001624596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04484233,0.001156822,0.795504,0.00002106911,0.0000961586,0.000004927845,0.00025593,0.000329898,0.1101227,0.000006705341,0.00002296093,0.04763651],"study_design_scores_gemma":[0.04427292,0.06902026,0.844764,0.00006168097,0.00001302659,2.207424e-7,0.0005001208,0.0005736896,0.03955428,0.00002676227,0.0008243013,0.0003887373],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983784,0.0003466403,0.000005380108,0.0000438339,0.0001061265,0.001020319,0.00001966033,0.000005132524,0.00007453559],"genre_scores_gemma":[0.9988877,0.000534248,0.0001671693,0.00003822114,0.0001469804,0.00009587035,0.00002126255,0.00003327636,0.00007524309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07056839,"threshold_uncertainty_score":0.9311152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09101283434535412,"score_gpt":0.5106174238592381,"score_spread":0.419604589513884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}