{"id":"W2107522576","doi":"10.1093/humrep/des159","title":"Amifostine-doxorubicin association causes long-term prepubertal spermatogonia DNA damage and early developmental arrest","year":2012,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Amifostine; Andrology; Spermatogenesis; Biology; Comet assay; Sperm; Embryo; Bleomycin; DNA damage; Doxorubicin; Internal medicine; Endocrinology; Medicine; DNA; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050424,0.0002402163,0.0002970432,0.0002234562,0.0001384621,0.0001173331,0.000145661,0.0002472249,0.001078239],"category_scores_gemma":[0.0001066187,0.0001228901,0.0002176299,0.000103864,0.0001609895,0.0001556596,0.0001849402,0.0003609388,0.0001279968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279642,"about_ca_system_score_gemma":0.0001900498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004157238,"about_ca_topic_score_gemma":0.001020259,"domain_scores_codex":[0.9999005,0.00001385359,0.00001151758,0.00002291563,0.00002442128,0.00002671487],"domain_scores_gemma":[0.999801,0.00001841448,0.00007518796,0.00001750878,0.00002003822,0.00006783324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007082081,0.00008288569,0.001282739,0.00005557278,0.0000127574,0.000176658,0.00002195861,0.00001992503,0.9957883,0.00002305503,0.00004113494,0.001786988],"study_design_scores_gemma":[0.00009855804,0.01286451,0.07782834,0.00002678456,0.00007442006,0.001627116,0.0001543436,0.0004062719,0.9031475,0.0000621807,0.00369769,0.00001239945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981674,0.001085869,0.0003495961,0.00003101274,0.00001697618,0.00001407604,0.0001001533,0.00002007806,0.0002147937],"genre_scores_gemma":[0.9969978,0.000773177,0.0003983695,0.00005018825,0.0000134494,0.00003559189,0.0002983565,0.00000419724,0.001428955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078239,"threshold_uncertainty_score":0.003607094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02390132423194738,"score_gpt":0.2757980714319617,"score_spread":0.2518967472000143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}