{"id":"W2107545015","doi":"10.1128/aac.01315-08","title":"Gene Expression and Evolution of Antifungal Drug Resistance","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Gene; Efflux; Drug resistance; Genetics; Population; Phenotype; Antifungal drug; Gene expression; Strain (injury); Saccharomyces cerevisiae; Gene dosage; Candida albicans","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120561,0.0001676926,0.00017737,0.0001626399,0.00008900798,0.0003135002,0.0001593764,0.0002653975,0.0005661743],"category_scores_gemma":[0.0002257278,0.0001429046,0.0002058258,0.0001653216,0.0002098659,0.0001722539,0.0002417124,0.0004134495,0.0002404768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003100295,"about_ca_system_score_gemma":0.0001009682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004501319,"about_ca_topic_score_gemma":0.0005593966,"domain_scores_codex":[0.9998558,0.00002215654,0.00001471606,0.0000490737,0.00003574137,0.00002261069],"domain_scores_gemma":[0.9998642,0.00002791033,0.00004144983,0.00002380059,0.00002336109,0.00001921144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002476803,0.000004200307,0.0008465027,0.000006541235,0.000001472381,0.00001495933,0.00001112992,0.0000333425,0.9982021,0.00002541312,0.000006860079,0.0008227325],"study_design_scores_gemma":[0.000008859965,0.0001867531,0.07393266,0.00000714139,0.00001518043,0.0003756704,0.0001067184,0.001431017,0.9217851,0.00009153,0.002050336,0.000009032618],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977713,0.0004014119,0.001022675,0.00004149036,0.000005369776,0.000005617273,0.0002067436,0.00002025346,0.0005252864],"genre_scores_gemma":[0.9960337,0.0003523391,0.001490522,0.00004149758,0.000003633609,0.00001789837,0.0007212023,0.00001748462,0.001321696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005661743,"threshold_uncertainty_score":0.002249479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006362990190703687,"score_gpt":0.2438153451036219,"score_spread":0.2374523549129182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}