{"id":"W2107578540","doi":"10.1158/0008-5472.can-10-1907","title":"Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers: Implications for Risk Prediction","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; NIH Office of the Director; Berrikuntza + Ikerketa + Osasuna Eusko Fundazioa; Norris Cotton Cancer Center; University of California, Irvine; National Institutes of Health; Istituto Oncologico Veneto; Fox Chase Cancer Center; Alleanza Contro il Cancro; Uppsala Universitet; Fondazione Italiana per la Ricerca sul Cancro; Università degli Studi di Torino; Radboud Universitair Medisch Centrum; lékařská fakulta Univerzity Karlovy; Leids Universitair Medisch Centrum; Associazione Italiana per la Ricerca sul Cancro; Ministerio de Ciencia e Innovación; Cancer Research UK; KWF Kankerbestrijding; University of Pennsylvania; Universiteit Gent; Israel Cancer Association; Lunds Universitet; Vlaamse regering; Sahlgrenska Universitetssjukhuset; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Mayo Clinic; Grantová Agentura České Republiky; Institut National de la Santé et de la Recherche Médicale; Universitair Medisch Centrum Groningen; Royal Marsden NHS Foundation Trust; Huntsman Cancer Institute; Universiteit Leiden; Centre National de la Recherche Scientifique; Deutsches Krebsforschungszentrum; Univerzita Karlova v Praze; Radboud Universiteit; Ohio State University; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Ministero della Salute; Akademiska Sjukhuset; Cancer Care Ontario; Vlaamse Liga Tegen Kanker; Breast Cancer Research Foundation","keywords":"Breast cancer; Single-nucleotide polymorphism; Genotype; Allele; Cancer; Oncology; Medicine; Genetics; Internal medicine; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007714814,0.0005593835,0.000426205,0.0008402738,0.0002621631,0.000411738,0.0003548067,0.0005797404,0.002751832],"category_scores_gemma":[0.002114081,0.000179504,0.0009721048,0.0007607206,0.0003287948,0.0002324848,0.000355757,0.0004372442,0.0001737231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002107765,"about_ca_system_score_gemma":0.0002152583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003622453,"about_ca_topic_score_gemma":0.005915517,"domain_scores_codex":[0.9995789,0.0001277781,0.00004341506,0.0001253406,0.00007042533,0.00005418221],"domain_scores_gemma":[0.9985021,0.0005403796,0.0005672582,0.0001256092,0.0000716703,0.0001929864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009304567,0.00003704751,0.9830953,0.00003068307,0.0004731984,0.0006361753,0.00009123978,0.0003651095,0.006470138,0.0001215363,0.0001790263,0.007569958],"study_design_scores_gemma":[0.00005534566,0.0001542424,0.9949461,0.00001518526,0.0003717588,0.001223117,0.00009512264,0.001176435,0.001093322,0.0004276983,0.0004291576,0.00001266576],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998289,0.0006100436,0.0004048302,0.0001091805,0.000008408612,0.00000674375,0.0002451271,0.000009474797,0.0003170451],"genre_scores_gemma":[0.999017,0.0001588641,0.0004047083,0.00003268564,0.00001407123,0.000005039328,0.0001851203,0.000004697982,0.0001778482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003622453,"threshold_uncertainty_score":0.009205759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224373511308771,"score_gpt":0.3622945977655861,"score_spread":0.3400508626524984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}