{"id":"W2107578540","doi":"10.1158/0008-5472.can-10-1907","title":"Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers: Implications for Risk Prediction","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; NIH Office of the Director; Berrikuntza + Ikerketa + Osasuna Eusko Fundazioa; Norris Cotton Cancer Center; University of California, Irvine; National Institutes of Health; Istituto Oncologico Veneto; Fox Chase Cancer Center; Alleanza Contro il Cancro; Uppsala Universitet; Fondazione Italiana per la Ricerca sul Cancro; Università degli Studi di Torino; Radboud Universitair Medisch Centrum; lékařská fakulta Univerzity Karlovy; Leids Universitair Medisch Centrum; Associazione Italiana per la Ricerca sul Cancro; Ministerio de Ciencia e Innovación; Cancer Research UK; KWF Kankerbestrijding; University of Pennsylvania; Universiteit Gent; Israel Cancer Association; Lunds Universitet; Vlaamse regering; Sahlgrenska Universitetssjukhuset; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Mayo Clinic; Grantová Agentura České Republiky; Institut National de la Santé et de la Recherche Médicale; Universitair Medisch Centrum Groningen; Royal Marsden NHS Foundation Trust; Huntsman Cancer Institute; Universiteit Leiden; Centre National de la Recherche Scientifique; Deutsches Krebsforschungszentrum; Univerzita Karlova v Praze; Radboud Universiteit; Ohio State University; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Ministero della Salute; Akademiska Sjukhuset; Cancer Care Ontario; Vlaamse Liga Tegen Kanker; Breast Cancer Research Foundation","keywords":"Breast cancer; Single-nucleotide polymorphism; Genotype; Allele; Cancer; Oncology; Medicine; Genetics; Internal medicine; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001579129,0.0001741206,0.0002320935,0.00007026664,0.0006458809,0.00006126671,0.0002598334,0.0002082521,0.00002806813],"category_scores_gemma":[0.0002158638,0.0001371437,0.0001009883,0.0002112566,0.001214474,0.00002056292,0.0001264231,0.0003565811,1.751007e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001472513,"about_ca_system_score_gemma":0.0006998233,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00616613,"about_ca_topic_score_gemma":0.02593287,"domain_scores_codex":[0.998269,0.0002232115,0.0003306742,0.0005997238,0.0002042381,0.0003731775],"domain_scores_gemma":[0.9976065,0.0003236239,0.000221823,0.0005577645,0.001166342,0.0001239131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003231371,0.0001009425,0.3391271,0.0003521902,0.0006820414,8.415075e-8,0.001229941,0.0009242184,0.5272189,0.0006744753,0.01411935,0.1123394],"study_design_scores_gemma":[0.01023044,0.0003809493,0.8375069,0.0001004089,0.0006259713,0.00005238915,0.001417471,0.002744676,0.1136445,0.007994753,0.02474472,0.0005567932],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636357,0.004328901,0.001172466,0.005028808,0.0002739887,0.002016816,0.02350122,0.00001330582,0.00002878351],"genre_scores_gemma":[0.9833089,0.009836201,0.0003901869,0.00008795502,0.0006898675,0.005400771,0.0001637671,0.00004160973,0.00008074692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4983799,"threshold_uncertainty_score":0.9918413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224373511308771,"score_gpt":0.3622945977655861,"score_spread":0.3400508626524984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}