{"id":"W2107586768","doi":"10.1128/iai.73.12.8345-8352.2005","title":"A Mutant of<i>Francisella tularensis</i>Strain SCHU S4 Lacking the Ability To Express a 58-Kilodalton Protein Is Attenuated for Virulence and Is an Effective Live Vaccine","year":2005,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; Umeå Universitet","keywords":"Francisella tularensis; Virulence; Attenuated vaccine; Biology; Tularemia; Microbiology; Mutant; Virology; Strain (injury); Pathogen; Francisella; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007000669,0.0001529479,0.0001880357,0.00003990666,0.0002624706,0.00004836304,0.00009725209,0.0001291881,0.00003350816],"category_scores_gemma":[0.0002402516,0.0001176515,0.00006181896,0.0001183831,0.0001052044,0.00001730168,0.0001156263,0.0001521183,0.000002060745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001731113,"about_ca_system_score_gemma":0.00002843369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006411512,"about_ca_topic_score_gemma":0.0001744906,"domain_scores_codex":[0.9989589,0.000219396,0.0002053825,0.0003059914,0.00009749325,0.0002127764],"domain_scores_gemma":[0.9991608,0.00004755086,0.00007582594,0.0003471112,0.0002694343,0.00009933623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005903134,0.00009860998,0.001585203,0.00007218428,0.00003061246,1.275191e-7,0.0009259667,0.000004845841,0.9486697,0.000008623971,0.00003941379,0.04797445],"study_design_scores_gemma":[0.001045095,0.0012198,0.05821215,0.00004857369,0.00001905979,0.00000821342,0.0001048232,0.00042757,0.9313911,0.00008598642,0.007264725,0.0001729257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963748,0.000232363,0.001543858,0.0002753041,0.00004083274,0.00133545,0.0001417601,0.00001041065,0.00004523973],"genre_scores_gemma":[0.9990513,0.0001535825,0.0001940312,0.0002882302,0.0001024947,0.0001480182,0.00002236035,0.00001339892,0.00002661371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05662694,"threshold_uncertainty_score":0.4797688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489172881805659,"score_gpt":0.2870663912060131,"score_spread":0.2721746623879565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}