{"id":"W2107586768","doi":"10.1128/iai.73.12.8345-8352.2005","title":"A Mutant of<i>Francisella tularensis</i>Strain SCHU S4 Lacking the Ability To Express a 58-Kilodalton Protein Is Attenuated for Virulence and Is an Effective Live Vaccine","year":2005,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; Umeå Universitet","keywords":"Francisella tularensis; Virulence; Attenuated vaccine; Biology; Tularemia; Microbiology; Mutant; Virology; Strain (injury); Pathogen; Francisella; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008572014,0.0004170384,0.0002577183,0.0002179385,0.0001279179,0.0001526021,0.000342883,0.0003248401,0.0008393232],"category_scores_gemma":[0.0001605206,0.0001050472,0.0003135037,0.0001574318,0.0003324682,0.0001089193,0.0001907468,0.000335606,0.0003346676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003156827,"about_ca_system_score_gemma":0.0002596596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002363877,"about_ca_topic_score_gemma":0.002079953,"domain_scores_codex":[0.9998987,0.00001368728,0.00001110782,0.00001411551,0.00003226245,0.00003011542],"domain_scores_gemma":[0.9998145,0.00002994324,0.00007705546,0.00001451779,0.00002388558,0.00004018022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001306948,0.00003482668,0.0004305803,0.00001840011,0.0000086137,0.00008497405,0.000008327008,0.0001048583,0.9979522,0.0001113538,0.00008343522,0.001031625],"study_design_scores_gemma":[0.00003481425,0.0007046039,0.008548875,0.00001060066,0.00003099593,0.0009907325,0.00004894296,0.002495363,0.9838988,0.00005941542,0.00316178,0.00001509076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997253,0.0001493563,0.001605636,0.00004623789,0.00002321958,0.00001785244,0.0003352938,0.00006694492,0.0005024049],"genre_scores_gemma":[0.9946625,0.0001138586,0.002406609,0.00005221709,0.00001172434,0.00002579639,0.001055261,0.0000325262,0.001639639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002363877,"threshold_uncertainty_score":0.004700184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489172881805659,"score_gpt":0.2870663912060131,"score_spread":0.2721746623879565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}