{"id":"W2107614818","doi":"10.1002/cbic.200890061","title":"Cover Picture: Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β‐Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry (ChemBioChem 16/2008)","year":2008,"lang":"en","type":"paratext","venue":"ChemBioChem","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; Hospital for Sick Children","funders":"","keywords":"Glucocerebrosidase; Hydrogen–deuterium exchange; Chemistry; Enzyme; Substrate (aquarium); Stereochemistry; Biochemistry; Mass spectrometry; Biology; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007862654,0.0008110591,0.000426595,0.0008813466,0.0003419692,0.0003871119,0.0006462845,0.0006049492,0.2809893],"category_scores_gemma":[0.000155638,0.0003083631,0.000304381,0.0005334503,0.0001252763,0.0005883146,0.0002472213,0.0009169906,0.06222566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005354244,"about_ca_system_score_gemma":0.0001692976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005465148,"about_ca_topic_score_gemma":0.001421081,"domain_scores_codex":[0.999946,0.000002321489,0.000001567046,0.000008460566,0.0000311552,0.00001057909],"domain_scores_gemma":[0.9999355,0.00001469886,0.000007286825,0.000004853002,0.00001080981,0.00002680529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006344381,0.0002076055,0.0001928525,0.0006197337,0.0000292469,0.0007316587,0.0000236803,0.0003351655,0.4491666,0.00222095,0.4539761,0.09186193],"study_design_scores_gemma":[0.0002900406,0.0008786442,0.01024227,0.00009103077,0.00004721025,0.002390101,0.00003468728,0.001936266,0.2539593,0.00171563,0.7283707,0.00004407262],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.06525216,0.03196431,0.03602676,0.01555263,0.0109818,0.001273126,0.07232676,0.009097244,0.7575253],"genre_scores_gemma":[0.05844705,0.01680583,0.01691645,0.001873657,0.001489116,0.0002592394,0.06503221,0.0009662567,0.8382102],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.2809893,"threshold_uncertainty_score":0.9400029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684259677766964,"score_gpt":0.2820146238316261,"score_spread":0.2651720270539564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}