{"id":"W2107665433","doi":"10.1056/nejmoa066157","title":"Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis","year":2007,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":1354,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Terry Fox Research Institute; University of British Columbia","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; National Cancer Institute; National Institutes of Health; Vanderbilt University; U.S. Public Health Service; Francis Family Foundation","keywords":"Dyskeratosis congenita; Telomerase; Pulmonary fibrosis; Telomerase reverse transcriptase; Telomere; Medicine; Proband; Idiopathic pulmonary fibrosis; Telomerase RNA component; Cancer research; Pathology; Mutation; Immunology; Fibrosis; Genetics; Biology; Lung; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003289419,0.0006379809,0.0002719946,0.001035384,0.001069484,0.0002501705,0.0002304091,0.0006996922,0.004225781],"category_scores_gemma":[0.002264641,0.0001931251,0.0001604266,0.0006675813,0.00052169,0.0002558402,0.0003279111,0.0003514244,0.0002386225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002408414,"about_ca_system_score_gemma":0.0002418186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001227972,"about_ca_topic_score_gemma":0.001267369,"domain_scores_codex":[0.9997314,0.00007615874,0.00002313366,0.0000648429,0.00005569763,0.00004879331],"domain_scores_gemma":[0.9994302,0.0002542555,0.0001604132,0.00002208948,0.00004851816,0.00008455957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005763849,0.000179021,0.820142,0.0001137174,0.00009591411,0.1341456,0.001637859,0.000697618,0.01072705,0.001092333,0.002437845,0.02815479],"study_design_scores_gemma":[0.00008309481,0.0005124545,0.3704167,0.0001534536,0.0002028752,0.6170733,0.0008277702,0.001312597,0.004136629,0.001572031,0.003680866,0.00002828763],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962398,0.0009815415,0.0004239002,0.0001839105,0.00001535914,0.00001125337,0.00007586772,0.00002575795,0.002042677],"genre_scores_gemma":[0.9992344,0.0002078852,0.0002323238,0.00003857965,0.00001955763,0.000005299774,0.00004720877,0.000002572375,0.0002121169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004225781,"threshold_uncertainty_score":0.01413667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489497116734988,"score_gpt":0.269203273200545,"score_spread":0.2543083020331951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}