{"id":"W2107676370","doi":"10.1080/10408440591007322","title":"Mode of Action: Oxalate Crystal-Induced Renal Tubule Degeneration and Glycolic Acid-Induced Dysmorphogenesis—Renal and Developmental Effects of Ethylene Glycol","year":2005,"lang":"en","type":"review","venue":"Critical Reviews in Toxicology","topic":"Poisoning and overdose treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; U.S. Environmental Protection Agency","keywords":"Glycolic acid; Toxicity; Ethylene glycol; Metabolite; Kidney; Oxalic acid; Developmental toxicity; Oxalate; Mode of action; Chemistry; Calcium oxalate; Pharmacology; Biochemistry; Endocrinology; Biology; Urine; Organic chemistry; Lactic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002276577,0.0009410869,0.001014667,0.001562712,0.0002123582,0.0006543595,0.0008049645,0.0008816301,0.004776917],"category_scores_gemma":[0.0002115906,0.0001845143,0.0003793245,0.001201026,0.0003840118,0.000866572,0.0004085236,0.0008260757,0.003666051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005290368,"about_ca_system_score_gemma":0.0004161988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007695687,"about_ca_topic_score_gemma":0.001128256,"domain_scores_codex":[0.9998851,0.00001929505,0.00001557373,0.00002584054,0.00004202154,0.00001204769],"domain_scores_gemma":[0.9999114,0.00002405896,0.00002236233,0.000004346735,0.00002896463,0.000008762929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001386245,0.0001075345,0.0002800545,0.01837505,0.00008763924,0.000779707,0.0001113343,0.0004943436,0.02602458,0.004899966,0.0256933,0.9230078],"study_design_scores_gemma":[0.00003189305,0.0002095976,0.001754561,0.00182837,0.00007890791,0.006288629,0.000094799,0.0001159233,0.006860106,0.002041803,0.9806718,0.00002356044],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005868481,0.9931157,0.0006130553,0.0001853029,0.0002591739,0.00002045331,0.00003674902,0.00003129342,0.005151331],"genre_scores_gemma":[0.00350608,0.9909146,0.000458188,0.0002202475,0.00014848,0.00002057524,0.0000539888,0.000004432106,0.004673495],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004776917,"threshold_uncertainty_score":0.01598042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.091196542917942,"score_gpt":0.4146661338798224,"score_spread":0.3234695909618804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}