{"id":"W2107676370","doi":"10.1080/10408440591007322","title":"Mode of Action: Oxalate Crystal-Induced Renal Tubule Degeneration and Glycolic Acid-Induced Dysmorphogenesis—Renal and Developmental Effects of Ethylene Glycol","year":2005,"lang":"en","type":"review","venue":"Critical Reviews in Toxicology","topic":"Poisoning and overdose treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; U.S. Environmental Protection Agency","keywords":"Glycolic acid; Toxicity; Ethylene glycol; Metabolite; Kidney; Oxalic acid; Developmental toxicity; Oxalate; Mode of action; Chemistry; Calcium oxalate; Pharmacology; Biochemistry; Endocrinology; Biology; Urine; Organic chemistry; Lactic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004272554,0.0005559004,0.00342353,0.0003403309,0.00006996765,0.00001234161,0.0001185739,0.0007764244,0.0000570991],"category_scores_gemma":[0.001876335,0.0004436529,0.0002688472,0.0003376375,0.0002076243,0.00009026267,0.0001290457,0.0004965548,0.00001226938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003720532,"about_ca_system_score_gemma":0.0004980082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002019447,"about_ca_topic_score_gemma":0.00005794322,"domain_scores_codex":[0.9965177,0.0006629528,0.001478771,0.000646451,0.0002438773,0.0004502005],"domain_scores_gemma":[0.998196,0.0008042203,0.000338359,0.0003030362,0.00008219714,0.0002761864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001034723,0.0004509514,0.00003613565,0.02661085,0.0001688968,0.0001058405,0.00008661496,1.590817e-7,0.08930788,0.0002045392,0.00005337171,0.8828713],"study_design_scores_gemma":[0.01266591,0.007782703,0.001463846,0.1549692,0.01159836,0.005836024,0.00005182512,0.0001493759,0.2466582,0.0002475628,0.5561505,0.002426462],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1033579,0.8942321,0.00004146792,0.00007294301,0.0001863414,0.001943933,0.00001710779,0.00001742918,0.0001308426],"genre_scores_gemma":[0.04405526,0.9523394,0.00268844,0.0001248401,0.0001564836,0.0004706212,0.00005648798,0.00004904176,0.00005947504],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8804448,"threshold_uncertainty_score":0.9998015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.091196542917942,"score_gpt":0.4146661338798224,"score_spread":0.3234695909618804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}