{"id":"W2107693078","doi":"10.1128/jvi.74.14.6251-6261.2000","title":"Deletion Mutagenesis Downstream of the 5′ Long Terminal Repeat of Human Immunodeficiency Virus Type 1 Is Compensated for by Point Mutations in both the U5 Region and <i>gag</i> Gene","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Medical Research Council","keywords":"Biology; Point mutation; Viral replication; Gene; RNA; Group-specific antigen; Mutation; Molecular biology; Genetics; Mutagenesis; Virus; Long terminal repeat; Reverse transcriptase; Virology; Primer extension; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156896,0.0002774473,0.0001543241,0.0001080012,0.0001190447,0.0001657902,0.0002394678,0.0001876739,0.0005850072],"category_scores_gemma":[0.0001702014,0.000145868,0.0001876555,0.00008705723,0.0002146819,0.00009794265,0.0001602684,0.0003758617,0.0002081788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865656,"about_ca_system_score_gemma":0.000160651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008459195,"about_ca_topic_score_gemma":0.001172754,"domain_scores_codex":[0.9998872,0.00002835889,0.00001459211,0.00002190035,0.00002813359,0.00001983888],"domain_scores_gemma":[0.9998615,0.00004377716,0.00004212535,0.0000158952,0.000007870377,0.00002891075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004358935,0.00001655829,0.0002582851,0.00001088292,0.000002365817,0.00006006704,0.00001046701,0.00006932094,0.998934,0.00004948336,0.000004271747,0.0005407397],"study_design_scores_gemma":[0.00001313078,0.0003594873,0.006137423,0.000005352999,0.00001546098,0.0005760011,0.00003073944,0.001178854,0.9907544,0.00002938814,0.0008932205,0.000006551849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984905,0.00009864171,0.001049802,0.000009691918,0.000005166913,0.00001307286,0.00005646018,0.0000174496,0.0002592009],"genre_scores_gemma":[0.9969547,0.0001040067,0.002222077,0.0000116604,0.000002732944,0.000009034532,0.000193167,0.00001279292,0.0004899356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008459195,"threshold_uncertainty_score":0.001957059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452465911030372,"score_gpt":0.2699762241510464,"score_spread":0.2554515650407427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}