{"id":"W2107724124","doi":"10.1039/c5cc01949d","title":"Diastereoselective construction of anti-4,5-disubstituted-1,3-dioxolanes via a bismuth-mediated two-component hemiacetal oxa-conjugate addition of γ-hydroxy-α,β-unsaturated ketones with paraformaldehyde","year":2015,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Engineering and Physical Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Paraformaldehyde; Hemiacetal; Conjugate; Chemistry; Component (thermodynamics); Bismuth; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003041805,0.0003621908,0.0006835418,0.00009161237,0.0001011622,0.00002071739,0.0009244946,0.0002782859,0.0001729697],"category_scores_gemma":[0.0005882822,0.0003381579,0.0001291185,0.0006270761,0.001360493,0.000210794,0.0002953435,0.0005771844,0.00001255551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877548,"about_ca_system_score_gemma":0.0002452607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001295535,"about_ca_topic_score_gemma":0.000009635638,"domain_scores_codex":[0.9978667,0.0001264785,0.0008515895,0.0003827314,0.0004282128,0.0003443246],"domain_scores_gemma":[0.9958786,0.00075746,0.0007417103,0.00174336,0.0006257628,0.0002531535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000201343,0.0003606449,0.001110793,0.0001267982,0.000213814,0.000001944456,0.000596965,0.00002512624,0.9965718,0.0001337431,0.00004329851,0.0006137787],"study_design_scores_gemma":[0.001907488,0.00003178719,0.0001103579,0.0002400483,0.000180742,0.0002297251,0.0007911175,0.002983097,0.9925182,0.0003346981,0.0003155048,0.0003571616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934688,0.000345387,0.001092614,0.0002218354,0.00005591531,0.0001893917,0.0002833756,0.0001872307,0.004155455],"genre_scores_gemma":[0.9783678,0.00007145783,0.01996358,0.00001214398,0.00004482383,0.00006600164,0.001402084,0.00004703501,0.00002505282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01887096,"threshold_uncertainty_score":0.999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979993308147244,"score_gpt":0.2756934635192194,"score_spread":0.245893530437747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}