{"id":"W2107749499","doi":"10.1172/jci43030","title":"Caveat mTOR: aberrant signaling disrupts corticogenesis","year":2010,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; King's College London","keywords":"Corticogenesis; PI3K/AKT/mTOR pathway; Megalencephaly; Mechanistic target of rapamycin; Epilepsy; Cancer research; Signal transducing adaptor protein; Forebrain; Phenotype; Signal transduction; Neuroscience; Medicine; Biology; Cell biology; Stem cell; Genetics; Central nervous system; Progenitor cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003307059,0.0005595658,0.0006168125,0.0003300209,0.0007373425,0.0007781769,0.0004920083,0.007400239,0.002011077],"category_scores_gemma":[0.001990896,0.0002435343,0.0004268761,0.0002787024,0.0008928929,0.0005379384,0.0003060227,0.004051093,0.00128149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001504958,"about_ca_system_score_gemma":0.0004801272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356085,"about_ca_topic_score_gemma":0.00272745,"domain_scores_codex":[0.9997594,0.00005517826,0.00002543816,0.00003347018,0.0000665328,0.00006008187],"domain_scores_gemma":[0.9995106,0.0003030686,0.00005559464,0.00002923977,0.00004143604,0.00005996877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008993029,0.0002530006,0.006290601,0.0004666708,0.0001625354,0.5004304,0.0003078079,0.0008258215,0.02512784,0.01309239,0.3758764,0.07626726],"study_design_scores_gemma":[0.001052976,0.0005083102,0.0118642,0.0002125911,0.0001801129,0.5785816,0.0002876963,0.005859674,0.01631655,0.01345321,0.3715813,0.0001017954],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1424327,0.02478961,0.003119586,0.7446657,0.02392862,0.0002363454,0.0004161007,0.001273434,0.05913792],"genre_scores_gemma":[0.6049585,0.01801455,0.003546156,0.2814628,0.0435979,0.000195473,0.0002315984,0.0002051335,0.04778785],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.007400239,"threshold_uncertainty_score":0.01091927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2119311959351175,"score_gpt":0.4246206764255147,"score_spread":0.2126894804903972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}