{"id":"W2107750620","doi":"10.1074/jbc.m111.241786","title":"Anti-Ro52 Autoantibodies from Patients with Sjögren's Syndrome Inhibit the Ro52 E3 Ligase Activity by Blocking the E3/E2 Interface","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto","funders":"Reumatikerförbundet; National Cancer Institute; Vetenskapsrådet; Stockholms Läns Landsting; Cancerfonden; Stiftelsen för Strategisk Forskning; VINNOVA; Karolinska Institutet; University of Minnesota","keywords":"Ubiquitin ligase; Autoantibody; Ribonucleoprotein; Biology; Ubiquitin; Immunology; Cell biology; Biochemistry; Antibody; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876625,0.0007250569,0.0004407394,0.0004055966,0.0001894463,0.000206869,0.0001598115,0.0005128451,0.002436358],"category_scores_gemma":[0.0003832361,0.0002287931,0.0003459674,0.0001926387,0.0001745345,0.000155967,0.0001757746,0.0004194106,0.0006509664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001843306,"about_ca_system_score_gemma":0.00007937067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005212839,"about_ca_topic_score_gemma":0.000543828,"domain_scores_codex":[0.9998059,0.00003428857,0.00002718561,0.00004623158,0.00003906486,0.00004741612],"domain_scores_gemma":[0.9998037,0.0000485218,0.00004779542,0.00002018768,0.00002289589,0.00005689428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001006405,0.0002667591,0.03609665,0.0001514563,0.0001704535,0.003602214,0.0001152934,0.0001936892,0.9466767,0.00008508416,0.0005255646,0.01110984],"study_design_scores_gemma":[0.0004764326,0.003726979,0.7219661,0.00004409301,0.0003132493,0.03543556,0.0001831726,0.002352401,0.2282276,0.0001893349,0.007049737,0.00003530568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978161,0.0008862038,0.0003602177,0.00006676702,0.00001796028,0.00001079528,0.0001061552,0.00003173662,0.0007040076],"genre_scores_gemma":[0.9987496,0.0002284249,0.0002559035,0.00009245506,0.00001785339,0.000008209595,0.0002692461,0.000006215862,0.0003720552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002436358,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657882275965305,"score_gpt":0.2177953412620095,"score_spread":0.2012165185023565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}