{"id":"W2107766358","doi":"10.1038/ng.501","title":"Genome-wide association study identifies five loci associated with lung function","year":2009,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":598,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Biocenter, University of Oulu; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; Helmholtz Zentrum München; Wellcome Trust; Cancer Research UK; Asthma and Lung UK; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; National Institutes of Health; Oulun Yliopisto; European Commission; University of Bristol; Vetenskapsrådet; Healthway; British Lung Foundation; National Institute of Mental Health; International Osteoporosis Foundation; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Genome Canada; British Heart Foundation; Scottish Government; AstraZeneca; Tays; King's College London; Juvenile Diabetes Research Foundation International","keywords":"Genome-wide association study; Biology; Genotyping; COPD; Vital capacity; Locus (genetics); Genetics; Pulmonary function testing; Genetic association; In silico; Lung function; Internal medicine; Bioinformatics; Single-nucleotide polymorphism; Genotype; Medicine; Lung; Gene; Diffusing capacity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008253987,0.0004839394,0.0005222766,0.001606948,0.0006265611,0.0005340193,0.0006104856,0.0007894972,0.002017028],"category_scores_gemma":[0.001136901,0.0003365039,0.0006714115,0.001553808,0.0005701154,0.0001839248,0.0005076051,0.000829115,0.0002334087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002107269,"about_ca_system_score_gemma":0.0002951425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002785817,"about_ca_topic_score_gemma":0.003605768,"domain_scores_codex":[0.9994813,0.0001439765,0.00004538581,0.0001789594,0.00008000875,0.00007037017],"domain_scores_gemma":[0.9986269,0.0006026486,0.0003206281,0.0001027861,0.00009069217,0.0002563281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004002322,0.0003555586,0.8674473,0.00009877397,0.00159012,0.00156604,0.0003070022,0.0002880797,0.1139083,0.000442364,0.0004925324,0.009501673],"study_design_scores_gemma":[0.00008586249,0.0001968629,0.9939587,0.000006483216,0.0004635726,0.001022134,0.00008847771,0.0004583392,0.003139088,0.0001960928,0.0003728545,0.00001140733],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975678,0.0006861428,0.0008515695,0.0001193852,0.00001338749,0.000006516376,0.000268286,0.00002488303,0.0004619274],"genre_scores_gemma":[0.9988237,0.0001241028,0.0004868516,0.00003598715,0.00001157597,0.000005332825,0.0001767332,0.000006991266,0.000328753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002785817,"threshold_uncertainty_score":0.006747603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004644334868257112,"score_gpt":0.2422298275555708,"score_spread":0.2375854926873137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}