{"id":"W2107785550","doi":"10.1093/hmg/ddu738","title":"Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Cilium; Cell biology; Bardet–Biedl syndrome; Biology; Protein subunit; Flagellum; Smoothened; Ciliopathies; Genetics; Hedgehog signaling pathway; Phenotype; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006939202,0.0002454425,0.0002130571,0.0001525781,0.0002292821,0.0004505013,0.0002781115,0.0003049896,0.0006743884],"category_scores_gemma":[0.0001523357,0.0001653165,0.0001757091,0.0000755824,0.0003068118,0.000300125,0.0004577123,0.0003461312,0.0002945294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003813893,"about_ca_system_score_gemma":0.0002557556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001204286,"about_ca_topic_score_gemma":0.001379621,"domain_scores_codex":[0.9998327,0.00001148175,0.00001459959,0.0000356868,0.0000715713,0.00003402758],"domain_scores_gemma":[0.9998831,0.00001032145,0.00003850494,0.000008199903,0.00001268285,0.00004724536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007519322,0.000006814415,0.000504577,0.0000188175,0.000003025799,0.0001251876,0.00001571105,0.0000511576,0.9979981,0.000214475,0.00002486659,0.0009622062],"study_design_scores_gemma":[0.00002399638,0.0001255929,0.07449763,0.000009984766,0.00002099763,0.000844375,0.0001343941,0.003845535,0.9172212,0.0001854029,0.003077537,0.00001336281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939305,0.001513505,0.002899751,0.00006061277,0.00001569066,0.00001031682,0.000133765,0.00006256659,0.001373459],"genre_scores_gemma":[0.9972063,0.0003954002,0.0009136807,0.00002483535,0.000003297583,0.000007010713,0.0001730378,0.00001045607,0.001265871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001204286,"threshold_uncertainty_score":0.002767205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00842288562183278,"score_gpt":0.2279967024256704,"score_spread":0.2195738168038376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}