{"id":"W2107808656","doi":"10.1172/jci42869","title":"BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Weill Cornell Medical College; National Cancer Institute; National Institutes of Health; College of Veterinary Medicine, Cornell University; Memorial Sloan-Kettering Cancer Center; Geoffrey Beene Cancer Research Center; Commonwealth Foundation; Leukemia and Lymphoma Society; Michael Smith Health Research BC; Canadian Institutes of Health Research; Chemotherapy Foundation","keywords":"Biology; Cancer research; BCL6; P300-CBP Transcription Factors; Histone acetyltransferase; Histone deacetylase inhibitor; Histone deacetylase; Molecular biology; Acetylation; B cell; Immunology; Histone; Genetics; Gene; Antibody; Germinal center","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133128,0.000448983,0.0003600472,0.0002995318,0.0001313804,0.0003446033,0.0004462407,0.0002176803,0.001214564],"category_scores_gemma":[0.00007683269,0.000143963,0.0002516701,0.0002492884,0.0001695588,0.0002052948,0.0003250021,0.0009071014,0.0005416581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004028009,"about_ca_system_score_gemma":0.0001948512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000395508,"about_ca_topic_score_gemma":0.001142546,"domain_scores_codex":[0.9998989,0.00001313958,0.000007053247,0.00001934603,0.00003257876,0.00002900789],"domain_scores_gemma":[0.9999682,0.000003262135,0.000006546255,0.000005201287,0.000005401102,0.00001148653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002853484,0.0002618823,0.0003406722,0.0001105752,0.00002428264,0.0001263469,0.00002841401,0.001334274,0.9724161,0.001495837,0.0004060348,0.02317011],"study_design_scores_gemma":[0.0002971944,0.001629744,0.001639735,0.000015607,0.00009035764,0.0006623103,0.00002731617,0.005953201,0.9683992,0.0005056528,0.02076386,0.00001581946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9289154,0.01091019,0.04432499,0.0005201634,0.0001544248,0.000559549,0.001111717,0.0006032131,0.01290024],"genre_scores_gemma":[0.9853078,0.003144627,0.007794038,0.00009171858,0.00001973312,0.0001421336,0.0006974661,0.0000342895,0.002768237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214564,"threshold_uncertainty_score":0.004063129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04215585285881388,"score_gpt":0.3809938247419264,"score_spread":0.3388379718831125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}