{"id":"W2107808656","doi":"10.1172/jci42869","title":"BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Weill Cornell Medical College; National Cancer Institute; National Institutes of Health; College of Veterinary Medicine, Cornell University; Memorial Sloan-Kettering Cancer Center; Geoffrey Beene Cancer Research Center; Commonwealth Foundation; Leukemia and Lymphoma Society; Michael Smith Health Research BC; Canadian Institutes of Health Research; Chemotherapy Foundation","keywords":"Biology; Cancer research; BCL6; P300-CBP Transcription Factors; Histone acetyltransferase; Histone deacetylase inhibitor; Histone deacetylase; Molecular biology; Acetylation; B cell; Immunology; Histone; Genetics; Gene; Antibody; Germinal center","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002556699,0.0001022976,0.0002975095,0.00009906307,0.00006109582,0.0000183956,0.0002064858,0.0003174279,0.00001248401],"category_scores_gemma":[0.002150042,0.00008591069,0.0002309663,0.00008915148,0.0001928205,0.000019191,0.00004095845,0.000275909,9.563231e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001721358,"about_ca_system_score_gemma":0.0004899198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001286942,"about_ca_topic_score_gemma":0.00002863843,"domain_scores_codex":[0.9978191,0.0002780754,0.001223198,0.0002001834,0.0003271833,0.0001522301],"domain_scores_gemma":[0.9980471,0.0002522853,0.0008382166,0.0002204735,0.0004937525,0.0001482324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005488129,0.001459557,0.005336085,0.00002762317,0.00001635834,0.000001880292,0.00007232802,0.000009847932,0.9884033,0.0001913506,0.003300894,0.0006319263],"study_design_scores_gemma":[0.00974504,0.001053847,0.006868875,0.00005008553,0.000008751713,0.000002954132,0.00002186904,0.0002066378,0.9758325,0.001370677,0.004747482,0.00009132016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983006,0.00006552027,0.0002078571,0.0002699411,0.0007927779,0.0002780506,0.00001614233,0.000002085387,0.00006705067],"genre_scores_gemma":[0.9966027,0.0000524345,0.002020021,0.0001002132,0.001052414,0.00001291509,0.00003518884,0.00001663843,0.0001074413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01257088,"threshold_uncertainty_score":0.3503337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04215585285881388,"score_gpt":0.3809938247419264,"score_spread":0.3388379718831125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}