{"id":"W2107812172","doi":"10.1096/fj.00-0583fje","title":"Inhibition of cytokine production and interference in IL‐2 receptor‐mediated Jak‐Stat signaling by the hydroxylamine metabolite of sulfamethoxazole","year":2001,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Western Ontario; Western University","funders":"Medical Research Council Canada; National Health Research Institutes","keywords":"stat; Cytokine; Metabolite; JAK-STAT signaling pathway; Sulfamethoxazole; Chemistry; Hydroxylamine; Signal transduction; Biology; Immunology; Biochemistry; STAT3; Receptor tyrosine kinase; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001088684,0.00009040317,0.0001863631,0.0001521784,0.00007668098,0.00000850676,0.00008194285,0.00006848818,0.0002844707],"category_scores_gemma":[0.0002503274,0.00005446425,0.00003977957,0.0002452244,0.0001667091,0.0001592459,0.00002697812,0.0004983841,0.00001021574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003261055,"about_ca_system_score_gemma":0.00001874487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001107113,"about_ca_topic_score_gemma":0.00002486243,"domain_scores_codex":[0.9987941,0.0004771966,0.000445775,0.0001017421,0.0000374772,0.0001437006],"domain_scores_gemma":[0.9993363,0.0001569365,0.0003016274,0.0001103866,0.0000865118,0.000008207803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000575577,0.00008414694,0.002166454,0.000006141908,0.00003063606,6.429416e-7,0.001231419,0.0000672923,0.9930777,0.00001590822,0.000465861,0.002278222],"study_design_scores_gemma":[0.0007262783,0.0001443121,0.001675783,0.0001128518,0.00001748537,0.0002268608,0.001908746,0.00003794062,0.9930999,0.00007036328,0.001923647,0.00005581422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956631,0.002320625,0.0002805182,0.000596908,0.0008703442,0.0001216138,0.000006087957,0.000005029979,0.0001357418],"genre_scores_gemma":[0.9974167,0.001526532,0.00001418834,0.00004538794,0.00002894688,0.000003673344,0.00003287429,0.000005953887,0.0009257704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002222407,"threshold_uncertainty_score":0.3114755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381514959744338,"score_gpt":0.2285032475522053,"score_spread":0.2146880979547619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}