{"id":"W2107825439","doi":"10.1128/iai.00188-08","title":"The Commensal <i>Streptococcus salivarius</i> K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis","year":2008,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":287,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Inimex Pharmaceuticals (Canada); Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Genome Prairie; Genome British Columbia","keywords":"Biology; Streptococcus salivarius; Flagellin; Innate immune system; Microbiology; Immune system; Secretion; Proinflammatory cytokine; Cell biology; Immunology; Inflammation; Bacteria; Streptococcus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371828,0.0004682661,0.0004424361,0.000199708,0.0001539296,0.000341616,0.0001030265,0.000180141,0.001211005],"category_scores_gemma":[0.0001491048,0.0001356853,0.0002530709,0.0001708397,0.0001979897,0.00009642167,0.0001715591,0.0003435755,0.0005079345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981861,"about_ca_system_score_gemma":0.0002414535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006357145,"about_ca_topic_score_gemma":0.001248986,"domain_scores_codex":[0.9997075,0.00007295276,0.00003317216,0.00005129687,0.00006678038,0.00006837062],"domain_scores_gemma":[0.9998988,0.0000185753,0.00002582373,0.00001587793,0.00001911899,0.00002178823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002375251,0.00002790858,0.0003767057,0.00004561052,0.000007276202,0.0000176085,0.000008277729,0.0000195328,0.9974633,0.000006226444,0.00004142751,0.001748484],"study_design_scores_gemma":[0.00001670746,0.001291714,0.02002228,0.00001298659,0.00004708138,0.0003028118,0.00004448789,0.0002675997,0.9753435,0.00001565104,0.002629076,0.000006022911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933514,0.004306357,0.0007727346,0.0001235786,0.00003049301,0.00002082253,0.0003512056,0.0001137331,0.0009296691],"genre_scores_gemma":[0.9933702,0.002067259,0.001498298,0.0001226206,0.00003178624,0.00004326967,0.0009956685,0.00002710853,0.001843744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211005,"threshold_uncertainty_score":0.004051268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02442780501561896,"score_gpt":0.2898846017049629,"score_spread":0.265456796689344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}