{"id":"W2107826773","doi":"10.1164/rccm.201501-0148oc","title":"A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes","year":2015,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences; Agency for Healthcare Research and Quality; National Institutes of Health; National Heart, Lung, and Blood Institute; Sunovion; Centers for Medicare and Medicaid Services; GlaxoSmithKline; COPD Foundation; AstraZeneca; Pfizer","keywords":"COPD; Spirometry; Genome-wide association study; Medicine; Airway; Phenotype; Genetic association; Pathology; Internal medicine; Genetics; Single-nucleotide polymorphism; Biology; Asthma; Genotype; Surgery; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008612775,0.00008711789,0.0003438857,0.00006194595,0.00004265203,0.000004433905,0.00006008392,0.00003284475,0.000002720164],"category_scores_gemma":[0.004677136,0.00006730414,0.00002851018,0.00008283074,0.0003143534,0.000005920906,0.00003648952,0.0000985969,1.948893e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002498901,"about_ca_system_score_gemma":0.00007191271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003295175,"about_ca_topic_score_gemma":0.00001760413,"domain_scores_codex":[0.9988576,0.0003513785,0.0003594017,0.0001288889,0.0001742788,0.0001284271],"domain_scores_gemma":[0.9984355,0.0003260384,0.0002975492,0.00008087671,0.0007072602,0.0001527679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001376135,0.0000661336,0.9855008,0.00001583393,0.00007729253,0.000008060019,0.003214402,0.00001243165,0.005528373,0.00003477522,0.0003239397,0.005080405],"study_design_scores_gemma":[0.002266218,0.02550278,0.792905,0.00004647917,0.0002708016,0.00001676081,0.174107,0.000008392722,0.0003793666,0.0002873637,0.004032272,0.0001774636],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908151,0.006984341,0.0008734246,0.001045273,0.00007426269,0.00005636787,0.000003278599,0.000001374405,0.0001465761],"genre_scores_gemma":[0.9984487,0.00006349631,0.0005265375,0.0007836358,0.0001612145,0.00000180031,0.000001752118,0.000006712941,0.000006143766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1925957,"threshold_uncertainty_score":0.5599307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175186664149184,"score_gpt":0.33145185488331,"score_spread":0.3096999882418182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}