{"id":"W2107826773","doi":"10.1164/rccm.201501-0148oc","title":"A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes","year":2015,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences; Agency for Healthcare Research and Quality; National Institutes of Health; National Heart, Lung, and Blood Institute; Sunovion; Centers for Medicare and Medicaid Services; GlaxoSmithKline; COPD Foundation; AstraZeneca; Pfizer","keywords":"COPD; Spirometry; Genome-wide association study; Medicine; Airway; Phenotype; Genetic association; Pathology; Internal medicine; Genetics; Single-nucleotide polymorphism; Biology; Asthma; Genotype; Surgery; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001376843,0.0004233842,0.0004620324,0.0007509076,0.0006769523,0.0005663271,0.0004046651,0.000693783,0.002514729],"category_scores_gemma":[0.002854454,0.0002360316,0.0006015225,0.001520142,0.000426207,0.0002383039,0.0005489905,0.0006808745,0.0001804694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001766222,"about_ca_system_score_gemma":0.0004521376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002731931,"about_ca_topic_score_gemma":0.003231087,"domain_scores_codex":[0.9990506,0.0003032068,0.00008310118,0.0003458312,0.0001197417,0.00009753975],"domain_scores_gemma":[0.9984733,0.0006869052,0.000311593,0.0002055993,0.0001032615,0.000219157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001106701,0.0001392368,0.9859732,0.00008438438,0.001168394,0.0006290115,0.0001399358,0.0002811716,0.005643929,0.0002141635,0.0003568878,0.00426287],"study_design_scores_gemma":[0.0001741769,0.0002521407,0.9962338,0.0000178576,0.0007288934,0.0007703412,0.00007747125,0.000465197,0.0003965348,0.0002461743,0.0006292149,0.000008263049],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969585,0.000512643,0.0008172169,0.0001953003,0.00001453584,0.00002901405,0.0009573648,0.00001701111,0.0004984395],"genre_scores_gemma":[0.997869,0.0001222475,0.0008470442,0.00006944543,0.00001633503,0.00002901184,0.0007953311,0.000005483475,0.0002461449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002731931,"threshold_uncertainty_score":0.0084126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175186664149184,"score_gpt":0.33145185488331,"score_spread":0.3096999882418182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}