{"id":"W2107833852","doi":"10.1002/pro.516","title":"Increased flexibility decreases antifreeze protein activity","year":2010,"lang":"en","type":"article","venue":"Protein Science","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Antifreeze protein; Chemistry; Biochemistry; Mutant; Alanine; Circular dichroism; Protein structure; C-terminus; Biophysics; Amino acid; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000959086,0.0003449673,0.0002785398,0.00009729004,0.00007001817,0.0002570015,0.0002544107,0.0002809228,0.001455617],"category_scores_gemma":[0.0002037727,0.0001445434,0.0002694018,0.00007707874,0.0002169572,0.0002160114,0.0002069116,0.0004839293,0.0002954046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002085895,"about_ca_system_score_gemma":0.0001049526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004442499,"about_ca_topic_score_gemma":0.0003210185,"domain_scores_codex":[0.9998586,0.00001731776,0.00001177141,0.00003660441,0.00004687355,0.00002881097],"domain_scores_gemma":[0.9997523,0.00004202509,0.00009883912,0.00002404307,0.0000228667,0.00005990621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003660828,0.0000110738,0.0001654592,0.00001094683,0.000003494897,0.00001262957,0.000004779492,0.00003997662,0.9993713,0.00001580496,0.000008888383,0.0003190177],"study_design_scores_gemma":[0.00001037158,0.0002828537,0.007451781,0.000003750388,0.000008398249,0.0002172729,0.00001639897,0.001102609,0.9900754,0.0000328263,0.0007928526,0.00000549283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983949,0.0003307149,0.000819053,0.00002900201,0.000007689283,0.000004418554,0.00007742917,0.00003789442,0.0002988486],"genre_scores_gemma":[0.9977705,0.0002117387,0.0009749763,0.00003714051,0.000004397933,0.000005286547,0.0002601515,0.0000204406,0.000715322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455617,"threshold_uncertainty_score":0.004869461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02226291215617978,"score_gpt":0.262373611638716,"score_spread":0.2401106994825362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}