{"id":"W2107838011","doi":"10.1158/1078-0432.ccr-14-2810","title":"Translational Impact of Nanoparticle–Drug Conjugate CRLX101 with or without Bevacizumab in Advanced Ovarian Cancer","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"Translational Impacts; Canadian Institutes of Health Research","keywords":"Bevacizumab; Medicine; Ovarian cancer; Camptothecin; Cancer; Combination therapy; Oncology; Cancer research; Internal medicine; Pharmacology; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001762773,0.0001813328,0.0004703373,0.00009413367,0.00007802361,0.00002255637,0.0003162966,0.000152745,0.0004218515],"category_scores_gemma":[0.000314866,0.0001275979,0.0001642064,0.0003788668,0.0004963533,0.00001424941,0.00007565349,0.0004235471,0.000006731573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005241132,"about_ca_system_score_gemma":0.001597895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002423691,"about_ca_topic_score_gemma":0.01117015,"domain_scores_codex":[0.9973248,0.0004756483,0.0005710702,0.0005765768,0.0004869894,0.0005648836],"domain_scores_gemma":[0.9985649,0.0001804062,0.0001241998,0.0004531915,0.0004263858,0.0002509169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03400677,0.0006981837,0.4632837,0.0001704441,0.0004209501,0.000005003375,0.0004351924,0.004106671,0.3364434,0.0001890861,0.003886762,0.1563538],"study_design_scores_gemma":[0.0317776,0.004971056,0.6367581,0.0005104155,0.000121969,0.00001585601,0.0001837781,0.002591518,0.1298368,0.0005389912,0.1916509,0.001043041],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956493,0.002447706,0.00009667306,0.0005579538,0.0003025399,0.0004568968,0.00008734389,0.000008008305,0.0003935367],"genre_scores_gemma":[0.9943915,0.00267716,0.0002874532,0.0001207122,0.001113787,0.0002181744,0.00002298457,0.00003709263,0.001131112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2066066,"threshold_uncertainty_score":0.6233208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08414878315593641,"score_gpt":0.4837361792371491,"score_spread":0.3995873960812127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}