{"id":"W2107845498","doi":"10.1371/journal.pone.0089889","title":"A Porphodimethene Chemical Inhibitor of Uroporphyrinogen Decarboxylase","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research; University Health Network","funders":"Canadian Institutes of Health Research; Cancer Prevention and Research Institute of Texas","keywords":"Chemistry; Uroporphyrinogen III decarboxylase; Viability assay; Biochemistry; Heme; Docking (animal); Cisplatin; Enzyme; Stereochemistry; Biology; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145511,0.00034329,0.0002419725,0.0001876226,0.0001023178,0.0001761086,0.0002512977,0.0002119284,0.0009489151],"category_scores_gemma":[0.0001121979,0.0001575638,0.0001881977,0.0001526441,0.0001062049,0.0001594953,0.0001999732,0.0003996382,0.0002579484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003063392,"about_ca_system_score_gemma":0.0002477959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002926948,"about_ca_topic_score_gemma":0.0004899718,"domain_scores_codex":[0.9999046,0.00001388641,0.000008450653,0.00002457406,0.00002657505,0.00002187685],"domain_scores_gemma":[0.9999557,0.0000059842,0.00001403359,0.000005703997,0.000006607875,0.00001201528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001216547,0.00006152853,0.0001262458,0.0001199539,0.00001086832,0.0000627826,0.000006746612,0.0004854978,0.9920933,0.0001577883,0.00007967238,0.0066739],"study_design_scores_gemma":[0.00005569782,0.0008892922,0.0007475081,0.000009245217,0.00001781084,0.0003123862,0.000005710869,0.001427789,0.9898965,0.00004169159,0.006590344,0.000005973711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533218,0.01114223,0.02672783,0.0003130812,0.00008280674,0.0003557336,0.0006545737,0.0002744554,0.007127469],"genre_scores_gemma":[0.978461,0.004361574,0.01207004,0.0000833605,0.00001255817,0.0001290033,0.0005295308,0.00002025175,0.00433268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009489151,"threshold_uncertainty_score":0.003174424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347765102839205,"score_gpt":0.2029314234210942,"score_spread":0.1894537723927021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}