{"id":"W2107869804","doi":"10.1128/jvi.02699-12","title":"The Acetyl-Esterase Activity of the Hemagglutinin-Esterase Protein of Human Coronavirus OC43 Strongly Enhances the Production of Infectious Virus","year":2013,"lang":"en","type":"article","venue":"Journal of Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; Armand Frappier Museum; McMaster University; Institut National de la Recherche Scientifique","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Biology; Coronavirus; Virology; Coronaviridae; Bovine coronavirus; Virus; Nidovirales; Recombinant DNA; Viral protein; Viral entry; Microbiology; Viral replication; Gene; Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002580008,0.0003746472,0.0002665854,0.0002325992,0.0001054308,0.0003078243,0.0001547234,0.0002595593,0.001182665],"category_scores_gemma":[0.0002505675,0.0001697466,0.0004066409,0.0001359403,0.0001956245,0.0001752247,0.0003381731,0.0004747402,0.0004729906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967636,"about_ca_system_score_gemma":0.0001749135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006711797,"about_ca_topic_score_gemma":0.0006447874,"domain_scores_codex":[0.9997616,0.0000440793,0.00002264678,0.00003324845,0.00007668844,0.00006172323],"domain_scores_gemma":[0.9997812,0.00007288498,0.00002722079,0.00004020701,0.0000299567,0.00004863221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001420701,0.000007287614,0.0001089691,0.00001318278,0.000002326746,0.00001879209,0.000006234675,0.00001065565,0.9994394,0.00002818835,0.00001075743,0.0003400125],"study_design_scores_gemma":[0.000005498199,0.0002099665,0.006979468,0.000006586761,0.00001293183,0.0002897444,0.00001932529,0.0005483513,0.989971,0.00003692159,0.001917233,0.000002843362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922341,0.001032934,0.003547513,0.00005827527,0.00002849687,0.00003015218,0.0001847142,0.00008698538,0.002796815],"genre_scores_gemma":[0.9924775,0.0006203788,0.003663048,0.00005212301,0.00001964572,0.00002718001,0.0007059198,0.00003860384,0.002395689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182665,"threshold_uncertainty_score":0.003956437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03470598919742587,"score_gpt":0.3524248175995642,"score_spread":0.3177188284021383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}