{"id":"W2107875432","doi":"10.1128/aac.49.11.4635-4640.2005","title":"Expression of the <i>mef</i> (E) Gene Encoding the Macrolide Efflux Pump Protein Increases in <i>Streptococcus pneumoniae</i> with Increasing Resistance to Macrolides","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; University of Manitoba; Manitoba Health; Health Sciences Centre","funders":"","keywords":"Efflux; Streptococcus pneumoniae; Microbiology; Gene; Ketolide; Bacterial protein; Biology; Streptococcaceae; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009370121,0.0001788181,0.000165256,0.0002082295,0.0001092464,0.0003028669,0.00008715067,0.0002896056,0.001032172],"category_scores_gemma":[0.0002684834,0.0001541376,0.0001867113,0.0001539442,0.0002556206,0.0001685647,0.0001495445,0.000308959,0.0003740428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002136409,"about_ca_system_score_gemma":0.0001074867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000653533,"about_ca_topic_score_gemma":0.0009202671,"domain_scores_codex":[0.9998709,0.00001855732,0.00001341662,0.00002942885,0.00003249425,0.00003511329],"domain_scores_gemma":[0.9997527,0.00005677761,0.00008202076,0.00001828497,0.00004700197,0.00004324243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005820701,0.000008939505,0.001757129,0.00002107913,0.000001958542,0.00004595885,0.00002590504,0.00001432084,0.9975029,0.00001089235,0.00001829317,0.000534571],"study_design_scores_gemma":[0.000014054,0.0004665204,0.1922766,0.00002297968,0.00002547337,0.001182573,0.0002195778,0.0005914233,0.8030386,0.00004910833,0.002102454,0.00001065426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979035,0.0004558911,0.0007427133,0.0000496692,0.000005180182,0.00001017218,0.0002461745,0.0000272905,0.0005593523],"genre_scores_gemma":[0.9952719,0.0004038823,0.002147005,0.00006446998,0.00001192449,0.00002548888,0.0006866608,0.0000124272,0.001376341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001032172,"threshold_uncertainty_score":0.003452957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007978076718904195,"score_gpt":0.2388112592350502,"score_spread":0.230833182516146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}