{"id":"W2107937198","doi":"10.1016/j.semradonc.2005.08.007","title":"Radiation and New Molecular Agents Part I: Targeting ATM-ATR Checkpoints, DNA Repair, and the Proteasome","year":2005,"lang":"en","type":"review","venue":"Seminars in Radiation Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"DNA repair; RAD51; DNA damage; Proteasome; DNA; Cell cycle; Medicine; Cell cycle checkpoint; Cell biology; Cancer research; Computational biology; Cell; Bioinformatics; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000727079,0.001618551,0.002204121,0.001902696,0.0003150084,0.001007027,0.001735838,0.001824703,0.004047195],"category_scores_gemma":[0.0006042349,0.0004306386,0.0005600855,0.002135031,0.0008747648,0.001952399,0.0006246605,0.002444612,0.004093948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009329302,"about_ca_system_score_gemma":0.0007997227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009508753,"about_ca_topic_score_gemma":0.002095893,"domain_scores_codex":[0.9997913,0.00002947313,0.00002214129,0.00003753596,0.00009548029,0.00002406355],"domain_scores_gemma":[0.9997104,0.0001355955,0.00003670198,0.00001334602,0.00006787517,0.00003603479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002019361,0.0001373258,0.0001258103,0.008543984,0.0001055251,0.0003500984,0.00004285709,0.0005837336,0.006477732,0.003984907,0.08911987,0.8903262],"study_design_scores_gemma":[0.00005738398,0.0001009526,0.0004557205,0.0008107158,0.00007275222,0.001261333,0.000028507,0.00007774914,0.001315656,0.001565054,0.9942373,0.00001684396],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008520591,0.9980686,0.0002248886,0.0002152908,0.0004618018,0.000005284366,0.000009474259,0.00001154436,0.0009179396],"genre_scores_gemma":[0.0004544791,0.9973791,0.000253277,0.0002428085,0.0004687963,0.000008456789,0.00002550366,0.000002068005,0.001165544],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004047195,"threshold_uncertainty_score":0.0135392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0200904368502611,"score_gpt":0.3227649242282927,"score_spread":0.3026744873780316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}