{"id":"W2107942632","doi":"10.1242/dev.127.14.3079","title":"Formation of the definitive endoderm in mouse is a Smad2-dependent process","year":2000,"lang":"en","type":"article","venue":"Development","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Biology; Epiblast; Gastrulation; Endoderm; Nodal signaling; Primitive streak; Cell biology; NODAL; Fate mapping; Cell fate determination; Ectoderm; Germ layer; Population; Embryo; Embryonic stem cell; Genetics; Embryogenesis; Stem cell; Gene; Induced pluripotent stem cell; Transcription factor; Progenitor cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006865811,0.00007843762,0.00006497157,0.00002156084,0.00003853784,0.000006553539,0.0001430475,0.00004725901,0.00006684591],"category_scores_gemma":[0.00001897938,0.00006205776,0.00002575357,0.00005439941,0.00002311323,0.000003427683,0.00003759113,0.00003552565,0.00001307421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002337251,"about_ca_system_score_gemma":0.0001666541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004911128,"about_ca_topic_score_gemma":0.00003990761,"domain_scores_codex":[0.9993886,0.00002206683,0.0001979785,0.0001330521,0.0001395434,0.0001186967],"domain_scores_gemma":[0.9997486,0.000004301708,0.00005361535,0.0001317248,0.00003809571,0.00002360131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009203749,0.001851666,0.06815726,0.0006809991,0.0002667692,0.00001543347,0.03813109,0.002812316,0.7364841,0.00008878189,0.002392911,0.1481983],"study_design_scores_gemma":[0.000332137,0.00001381593,0.009504329,0.00002963291,0.000003026501,0.000002618787,0.0001394883,0.00001613221,0.9864228,0.00002651296,0.003423362,0.00008617683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998272,0.0001419775,0.0000928044,0.00003019796,0.00001721846,0.000161485,0.00001170793,0.000004958583,0.001267649],"genre_scores_gemma":[0.9986938,0.00001802441,0.0002930957,0.0002251186,0.00001050392,0.00005646951,0.00003746929,0.000007707256,0.0006578358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2499387,"threshold_uncertainty_score":0.2530642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078655319527891,"score_gpt":0.2332938430875395,"score_spread":0.2225072898922606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}