{"id":"W2107961902","doi":"10.1016/j.ccell.2015.09.009","title":"A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy","year":2015,"lang":"en","type":"article","venue":"Cancer Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Cancer Institute","keywords":"CHEK1; Cell cycle checkpoint; Biology; G2-M DNA damage checkpoint; Gadd45; DNA damage; Cell cycle; Cell biology; Cancer research; Kinase; Checkpoint Kinase 2; DNA; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001889903,0.000180084,0.0002585207,0.00004344193,0.00005395663,0.00002285017,0.000277045,0.00007919392,0.00003568041],"category_scores_gemma":[0.00009573523,0.0001700259,0.00008531248,0.0001585558,0.00004834796,0.000006328554,0.0001006885,0.00009701117,0.00002550567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001753566,"about_ca_system_score_gemma":0.0002454176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004221195,"about_ca_topic_score_gemma":0.0007186632,"domain_scores_codex":[0.9986234,0.00006170121,0.0002230897,0.0004313148,0.0002366431,0.0004238478],"domain_scores_gemma":[0.9989417,0.00001117653,0.0001066719,0.0003563553,0.0002098669,0.0003741826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006688869,0.00005700592,0.0009199815,0.0000551774,0.00002165687,0.000004673073,0.0002642693,0.00008649853,0.9956329,0.000008807817,0.001897754,0.0003823867],"study_design_scores_gemma":[0.001536164,0.0004928645,0.001014443,0.00007916104,0.000006215885,3.56526e-7,0.0002404147,0.00002065516,0.9911605,0.00002911378,0.005217307,0.0002028303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991239,0.0005413104,0.00104727,0.0002240366,0.00005595468,0.0009114321,0.00005862438,0.00001059036,0.005911769],"genre_scores_gemma":[0.9850059,0.00002455799,0.0008675014,0.0001799422,0.0001657542,0.0002428649,0.00001201267,0.00003628188,0.01346518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007553406,"threshold_uncertainty_score":0.6933454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110281564252256,"score_gpt":0.2732366802021953,"score_spread":0.2622085237769697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}