{"id":"W2107967405","doi":"10.1158/0008-5472.can-07-6790","title":"Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; U.S. Public Health Service; Robert Bosch Stiftung; National Institute of Environmental Health Sciences; American Lebanese Syrian Associated Charities","keywords":"Thiopurine methyltransferase; Toxicity; Pharmacology; Biology; ITPA; Myeloid; Medicine; Cancer research; Biochemistry; Azathioprine; Gene; Internal medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008855226,0.0002285639,0.0004251806,0.0005071382,0.0004435701,0.00002506557,0.0003127053,0.0002737369,0.000644128],"category_scores_gemma":[0.0004721092,0.0001927011,0.0001320995,0.001478004,0.0004356478,0.0001441023,0.00009248836,0.001436461,0.0005115563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001972471,"about_ca_system_score_gemma":0.002924047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005814197,"about_ca_topic_score_gemma":0.0001218736,"domain_scores_codex":[0.9955851,0.0002198526,0.000397693,0.0006308599,0.00207712,0.001089339],"domain_scores_gemma":[0.9977311,0.0001840615,0.00005179457,0.0006528905,0.0007939819,0.0005861007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001089963,0.000427303,0.004739591,0.0005351003,0.0001076513,0.001857854,0.00145176,0.00001163779,0.9769951,0.0000358149,0.009729439,0.003018826],"study_design_scores_gemma":[0.01079967,0.001667759,0.04168489,0.0007592752,0.0000438837,0.0009933172,0.0005053118,0.002148245,0.928345,0.000121418,0.01232613,0.0006051156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885815,0.0002020565,0.0002311285,0.004246914,0.0001349656,0.001870099,0.00002008492,0.0001909532,0.004522261],"genre_scores_gemma":[0.9945301,0.0006773014,0.0000768904,0.0002877643,0.0004897907,0.0008797696,0.00003396233,0.00007399468,0.002950413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04865007,"threshold_uncertainty_score":0.7858123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1077604610758379,"score_gpt":0.3735899687325245,"score_spread":0.2658295076566866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}