{"id":"W2107997901","doi":"10.1016/j.ejca.2005.08.037","title":"A National Cancer Institute of Canada Clinical Trials Group Study – IND.135: Phase I/II study of irinotecan (camptosar), oxaliplatin and raltitrexed (tomudex) (COT) in patients with advanced colorectal cancer","year":2005,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; Occupational Cancer Research Centre; Ottawa Regional Cancer Foundation; Ottawa Hospital","funders":"","keywords":"Medicine; Oxaliplatin; Irinotecan; Raltitrexed; Discontinuation; Nausea; Colorectal cancer; Internal medicine; Vomiting; Toxicity; Phases of clinical research; Gastroenterology; Oncology; Cancer; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002506537,0.00173966,0.002447448,0.0003862707,0.0008405421,0.001101706,0.001282895,0.0009567628,0.006374075],"category_scores_gemma":[0.001750016,0.000832781,0.002137935,0.001023097,0.001167389,0.0004668452,0.0004893001,0.002983922,0.000930661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004934406,"about_ca_system_score_gemma":0.01249931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1218623,"about_ca_topic_score_gemma":0.4127505,"domain_scores_codex":[0.9983475,0.000962667,0.00006081731,0.0001551944,0.0002189669,0.000254795],"domain_scores_gemma":[0.9986767,0.0001428959,0.0002485484,0.00009536584,0.0001237023,0.0007126647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9066806,0.01124373,0.01072767,0.001031876,0.004101564,0.00016169,0.0001844666,0.0008651568,0.006535998,0.0007172364,0.01759378,0.04015621],"study_design_scores_gemma":[0.9247228,0.02962319,0.03427825,0.00006274464,0.001791325,0.0001510764,0.00005388964,0.0003858898,0.0004876793,0.0001795037,0.008222618,0.00004099904],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.924997,0.011454,0.001072454,0.00394766,0.0006672227,0.01161177,0.02818164,0.0002721422,0.01779622],"genre_scores_gemma":[0.9413581,0.008062554,0.006752558,0.005012849,0.0004617689,0.00588268,0.0203788,0.0001041773,0.01198652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1218623,"threshold_uncertainty_score":0.2423059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05377478333151524,"score_gpt":0.3981702665883614,"score_spread":0.3443954832568462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}