{"id":"W2108021322","doi":"10.1002/cbic.201000386","title":"Multimerization of cRGD Peptides by Click Chemistry: Synthetic Strategies, Chemical Limitations, and Influence on Biological Properties","year":2010,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Chemistry; In vitro; Peptide; Integrin; Monomer; Click chemistry; Conjugated system; In vivo; Biophysics; Dendrimer; Combinatorial chemistry; Biochemistry; Cell; Organic chemistry; Biology; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001139551,0.0001528127,0.0002379867,0.00003089749,0.00003925958,0.00002894735,0.0001113243,0.0001988371,0.00006547038],"category_scores_gemma":[0.001606973,0.0001149285,0.00004617943,0.0001344002,0.0004848526,0.0000475923,0.00006545938,0.0003220277,0.00001135033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001931551,"about_ca_system_score_gemma":0.00009167943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001460896,"about_ca_topic_score_gemma":3.576705e-7,"domain_scores_codex":[0.9989826,0.000016223,0.0002432953,0.0003213165,0.0002428609,0.0001937047],"domain_scores_gemma":[0.9991795,0.0001362097,0.0000739318,0.0002826631,0.0001764351,0.0001512361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001059613,0.0002090484,0.001301645,0.0001436459,0.00001409383,0.000001834484,0.0001071462,7.009201e-7,0.9966148,0.00004671149,0.0001651334,0.001289243],"study_design_scores_gemma":[0.0004358203,0.0001145433,0.003363168,0.00007670454,0.00001137396,0.00001292996,0.0003237991,0.0001854337,0.9946896,0.00002270896,0.0006483218,0.0001155633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99738,0.000171532,0.000008533196,0.000267821,0.00001018987,0.0002301591,0.00000707571,0.00004140751,0.001883341],"genre_scores_gemma":[0.9987531,0.0001404064,0.0005923109,0.00005617207,0.00002624539,0.0000260533,0.00009041215,0.00001680695,0.0002985237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061522,"threshold_uncertainty_score":0.4686647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03311045877988409,"score_gpt":0.2745654899018972,"score_spread":0.2414550311220131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}