{"id":"W2108030741","doi":"10.1002/chin.200147202","title":"ChemInform Abstract: Properties of Arabinonucleic Acids (ANA & 20′F‐ANA): Implications for the Design of Antisense Therapeutics That Invoke RNase H Cleavage of RNA","year":2001,"lang":"en","type":"article","venue":"ChemInform","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; RNase P; Cleavage (geology); RNA; RNase H; Combinatorial chemistry; Computational biology; Stereochemistry; Biochemistry; Gene; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004320971,0.0006223162,0.0002626051,0.0003126859,0.0003713731,0.0007926513,0.000301758,0.0005086142,0.01046979],"category_scores_gemma":[0.0006869416,0.0002262097,0.0001745618,0.0002689327,0.0003239086,0.0008123922,0.00014766,0.0007219799,0.003906122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005384525,"about_ca_system_score_gemma":0.0004019364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006554033,"about_ca_topic_score_gemma":0.0007111114,"domain_scores_codex":[0.99984,0.00003957999,0.00001081254,0.00002497772,0.00006033173,0.00002428369],"domain_scores_gemma":[0.9997165,0.0001092235,0.00005990171,0.00001545251,0.00004931184,0.00004959036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007262955,0.00008215447,0.0002655748,0.0004739021,0.00001704689,0.0001339207,0.0000372208,0.0007450203,0.9542821,0.00585834,0.005024987,0.03235349],"study_design_scores_gemma":[0.00003600667,0.0002601371,0.0004723505,0.00001282021,0.00001222453,0.0001772162,0.00001036385,0.0006069836,0.9805034,0.0008722087,0.01702365,0.00001261717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6221414,0.07589032,0.09295414,0.005637839,0.002273184,0.0003401835,0.005693681,0.001395022,0.1936742],"genre_scores_gemma":[0.9170672,0.01488112,0.02078088,0.0009200656,0.000410134,0.0001180403,0.002770831,0.0002531371,0.04279859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01046979,"threshold_uncertainty_score":0.03502494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0563927988156581,"score_gpt":0.2685718788765083,"score_spread":0.2121790800608502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}