{"id":"W2108037980","doi":"10.1095/biolreprod.107.062265","title":"Dynamic Regulation of Histone H3 Methylation at Lysine 4 in Mammalian Spermatogenesis1","year":2007,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Armstrong Foundation; Lance Armstrong Foundation","keywords":"Biology; Histone H3; Histone methyltransferase; Histone H1; Histone methylation; Histone code; EZH2; Chromatin; Histone H2A; Cell biology; Epigenomics; Histone octamer; Histone; Molecular biology; Genetics; DNA methylation; Nucleosome; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009638384,0.00009632546,0.0001679334,0.0001726259,0.00002777085,9.848112e-7,0.00006205193,0.0002044629,0.00001593371],"category_scores_gemma":[0.0001460933,0.0001007088,0.00005911792,0.0001841864,0.0001161125,0.000004606539,0.00003891926,0.00003623272,0.000001985177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005149561,"about_ca_system_score_gemma":0.00002066325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000650502,"about_ca_topic_score_gemma":0.0002025825,"domain_scores_codex":[0.9988816,0.00008113736,0.0004553286,0.0003735163,0.00007549444,0.0001328676],"domain_scores_gemma":[0.9991283,0.00001149183,0.0003181246,0.0003807503,0.0001383258,0.00002295421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001667137,0.00004695442,0.03870087,0.00002170778,0.00001231942,1.453862e-7,0.00003595775,0.0003298676,0.9348458,0.0000835582,0.000008487671,0.02574762],"study_design_scores_gemma":[0.0002337414,0.0001398898,0.239331,0.00000477925,0.000008475506,0.000002920654,0.00001355005,0.00005381035,0.7560302,0.0002959065,0.003815238,0.00007053438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835549,0.007358787,0.00827983,0.0001002629,0.0002640423,0.0001622589,0.000005162929,0.000005775399,0.0002689952],"genre_scores_gemma":[0.9959298,0.0005159061,0.002685519,0.000002919934,0.00008668141,0.00000305494,0.0003576064,0.00001119306,0.0004073404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2006301,"threshold_uncertainty_score":0.4106784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210263230901847,"score_gpt":0.3078245464812264,"score_spread":0.2957219141722079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}