{"id":"W2108037980","doi":"10.1095/biolreprod.107.062265","title":"Dynamic Regulation of Histone H3 Methylation at Lysine 4 in Mammalian Spermatogenesis1","year":2007,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Armstrong Foundation; Lance Armstrong Foundation","keywords":"Biology; Histone H3; Histone methyltransferase; Histone H1; Histone methylation; Histone code; EZH2; Chromatin; Histone H2A; Cell biology; Epigenomics; Histone octamer; Histone; Molecular biology; Genetics; DNA methylation; Nucleosome; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001246675,0.0001975714,0.0002065656,0.0003769969,0.0002640077,0.0002655104,0.0001770677,0.0001690374,0.000941642],"category_scores_gemma":[0.0001058308,0.0001594675,0.0001815889,0.000266711,0.0002307831,0.0001859236,0.0003126173,0.0001347808,0.0002936854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002899612,"about_ca_system_score_gemma":0.0001960376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001704756,"about_ca_topic_score_gemma":0.002228079,"domain_scores_codex":[0.9999244,0.000009817998,0.000005009376,0.00002481391,0.00002220752,0.00001379168],"domain_scores_gemma":[0.9999375,0.000004556223,0.00002033931,0.00000444091,0.00001302806,0.00002008165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001570692,0.000006907706,0.005466098,0.00005498285,0.00001538704,0.0000633881,0.0000472183,0.00008960374,0.9903695,0.0001407598,0.00007721122,0.003511971],"study_design_scores_gemma":[0.00004145451,0.0003753658,0.4923485,0.0000278201,0.00008660569,0.0007195448,0.000177255,0.002013073,0.4907235,0.0004388124,0.01300977,0.00003831204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980992,0.01135192,0.004612799,0.00007397334,0.00004299112,0.00002402896,0.0008166403,0.0001332161,0.001952393],"genre_scores_gemma":[0.9942369,0.001817011,0.001498986,0.00004479355,0.00002102541,0.0000150855,0.0006877799,0.00001519396,0.00166328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704756,"threshold_uncertainty_score":0.003389657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210263230901847,"score_gpt":0.3078245464812264,"score_spread":0.2957219141722079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}