{"id":"W2108057554","doi":"10.1093/protein/gzh050","title":"Modification of substrate-binding site of glutamyl endopeptidase from Bacillus intermedius","year":2004,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Russian Foundation for Basic Research","keywords":"Substrate specificity; Endopeptidase; Substrate (aquarium); Chemistry; Biochemistry; Microbiology; Stereochemistry; Biology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336045,0.0002823618,0.0002519072,0.0001019521,0.00008614379,0.0001915218,0.0001711366,0.0002374217,0.000521513],"category_scores_gemma":[0.0002049817,0.00009318058,0.0001876546,0.0001594003,0.0001338563,0.0001180195,0.0001352649,0.0003728109,0.0002322411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000134002,"about_ca_system_score_gemma":0.0001234508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003829419,"about_ca_topic_score_gemma":0.0002926633,"domain_scores_codex":[0.9998641,0.00002872005,0.00001899721,0.00002327383,0.00003847532,0.00002646227],"domain_scores_gemma":[0.9998921,0.00002049063,0.00003460636,0.00001388037,0.00001195828,0.000027058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001155363,0.00002146168,0.0001937592,0.00001854839,0.000003036579,0.00007024096,0.000007826978,0.00006442114,0.9986588,0.00002393122,0.00000536087,0.0008171762],"study_design_scores_gemma":[0.000005873811,0.0001630043,0.00163561,0.000002316853,0.000007358591,0.0002225501,0.00000946755,0.0002751591,0.9972867,0.00001510599,0.0003741769,0.000002691708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979076,0.0003020106,0.001279928,0.00003088008,0.000007341534,0.00001057715,0.00008683607,0.00001083732,0.0003640034],"genre_scores_gemma":[0.9963237,0.0002768534,0.002389989,0.00001980711,0.000002746777,0.000007394052,0.0003367418,0.00001103528,0.0006317497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000521513,"threshold_uncertainty_score":0.001744628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710460748196551,"score_gpt":0.2266243282766053,"score_spread":0.2095197207946398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}