{"id":"W2108064111","doi":"10.1093/hmg/dds500","title":"LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Mitochondrial biogenesis; Mitochondrion; Mitochondrial DNA; Cell biology; Loss function; DNAJA3; Regulator; mitochondrial fusion; Phenotype; Neuroscience; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339895,0.0003651311,0.0002460944,0.0001883336,0.0002269388,0.0003545313,0.0001642165,0.0002076464,0.0008797069],"category_scores_gemma":[0.0001325657,0.0001361675,0.0001361936,0.0001431423,0.0002961547,0.0003013216,0.0002487001,0.0003419252,0.0004846544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003601335,"about_ca_system_score_gemma":0.0002098215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002289535,"about_ca_topic_score_gemma":0.0004496526,"domain_scores_codex":[0.9999256,0.00001714958,0.000008138895,0.00001367755,0.00001375798,0.00002172636],"domain_scores_gemma":[0.9998943,0.000009845549,0.00005283437,0.000008764233,0.00001070917,0.00002360204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002620002,0.0000146014,0.000775124,0.00009172476,0.000005938894,0.0001908641,0.0000221238,0.0001016572,0.9960924,0.0002276126,0.00005198155,0.002164002],"study_design_scores_gemma":[0.00004785351,0.0002525899,0.02525775,0.00002616962,0.00002732429,0.001474961,0.00008355993,0.0007224682,0.9675577,0.0004567109,0.004079039,0.00001384601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888983,0.005955141,0.003323196,0.0002378684,0.00003274827,0.00002241028,0.0003358586,0.0001260686,0.001068442],"genre_scores_gemma":[0.9951496,0.001828905,0.001877739,0.00003516788,0.000006158376,0.00003047869,0.0003484912,0.00001405793,0.0007094202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008797069,"threshold_uncertainty_score":0.00294292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199919372078723,"score_gpt":0.2623071543271527,"score_spread":0.2423152171192804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}