{"id":"W2108070369","doi":"10.1093/nar/gkr1066","title":"MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain","year":2011,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of Alberta","funders":"Canadian Institutes of Health Research; University of Victoria; University of Calgary","keywords":"Biology; Chromatin; Nucleosome; Histone; Histone H1; Linker DNA; Histone code; Cell biology; DNA; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007808764,0.0002423072,0.0002169247,0.0003353453,0.0002353112,0.0002612421,0.0002660519,0.0001599716,0.001063976],"category_scores_gemma":[0.000166486,0.000227149,0.0001861496,0.0001744894,0.0002295266,0.0001486328,0.0002969715,0.0002528124,0.0003429793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004170978,"about_ca_system_score_gemma":0.0003053149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004078493,"about_ca_topic_score_gemma":0.005609938,"domain_scores_codex":[0.9999108,0.000006161002,0.000005009132,0.00003601687,0.00002237055,0.00001957998],"domain_scores_gemma":[0.9999225,0.00001396777,0.00001626557,0.000007471092,0.00001488776,0.00002496366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005087531,0.000003562852,0.0008168925,0.00003856635,0.00001143986,0.00007886405,0.0000262927,0.0000245123,0.9977533,0.00005584273,0.00004491379,0.001094854],"study_design_scores_gemma":[0.00001852086,0.0000762487,0.1173266,0.00002262789,0.00005351878,0.001782036,0.0001238666,0.000877323,0.8749765,0.0003667618,0.004364643,0.000011339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851807,0.008335526,0.003901883,0.0001320771,0.0000189534,0.00001070677,0.0005860415,0.00006907478,0.00176504],"genre_scores_gemma":[0.9897707,0.002377772,0.002762437,0.0001020895,0.00001543342,0.00003290131,0.001400767,0.00002677021,0.003511254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004078493,"threshold_uncertainty_score":0.00810951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06030053664428105,"score_gpt":0.3226979863121545,"score_spread":0.2623974496678734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}