{"id":"W2108070369","doi":"10.1093/nar/gkr1066","title":"MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain","year":2011,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of Alberta","funders":"Canadian Institutes of Health Research; University of Victoria; University of Calgary","keywords":"Biology; Chromatin; Nucleosome; Histone; Histone H1; Linker DNA; Histone code; Cell biology; DNA; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001079525,0.000210912,0.0001786244,0.0003210756,0.0002382267,0.00007699658,0.001023485,0.0001930755,0.0001087588],"category_scores_gemma":[0.0005713707,0.0001714975,0.00005873192,0.0008331409,0.0001966112,0.000007817685,0.0009445109,0.0003344704,0.0001233266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002081969,"about_ca_system_score_gemma":0.00008002642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001289856,"about_ca_topic_score_gemma":0.0004062938,"domain_scores_codex":[0.9975619,0.0003318795,0.0002566747,0.0006660574,0.0004929981,0.0006904541],"domain_scores_gemma":[0.9986175,0.00006145277,0.00002554719,0.000881227,0.000136956,0.0002773602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002143126,0.0002004993,0.003392577,0.00001768665,0.00004053464,0.00002540956,0.004324172,0.000003473947,0.939697,0.001009825,0.04613959,0.004934953],"study_design_scores_gemma":[0.002073064,0.002663406,0.5972605,0.0000626976,0.00001486673,0.00003864296,0.00500568,0.00004237489,0.144966,0.00559455,0.2413928,0.0008854404],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824337,0.0001807413,0.00004818355,0.008564944,0.00006181378,0.0006733249,0.00002045301,0.00001489371,0.008001943],"genre_scores_gemma":[0.9942542,0.0001898568,0.001447721,0.002882818,0.0000323786,0.00009181863,0.00001705401,0.00005367893,0.001030429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.794731,"threshold_uncertainty_score":0.6993467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06030053664428105,"score_gpt":0.3226979863121545,"score_spread":0.2623974496678734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}