{"id":"W2108078547","doi":"10.1091/mbc.e06-02-0097","title":"Dynamic Regulation of Mammalian Numb by G Protein-coupled Receptors and Protein Kinase C Activation: Structural Determinants of Numb Association with the Cortical Membrane","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"NUMB; Biology; Cell biology; Phosphorylation; Membrane protein; Proto-oncogene tyrosine-protein kinase Src; Vesicle-associated membrane protein 8; Endocytic cycle; G protein-coupled receptor; Biochemistry; Endocytosis; Signal transduction; Receptor; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002373954,0.000131741,0.0001946798,0.00002390668,0.00006994876,0.000005262109,0.0001646723,0.0002028235,0.00001964781],"category_scores_gemma":[0.00004493719,0.00008153567,0.00007281856,0.0001017457,0.0001670136,0.000004096306,0.00005795691,0.00008715357,1.555099e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001756666,"about_ca_system_score_gemma":0.00003450852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001046764,"about_ca_topic_score_gemma":0.00002467103,"domain_scores_codex":[0.9990337,0.0001974634,0.0002743881,0.0002091391,0.0001352145,0.0001500776],"domain_scores_gemma":[0.9991722,0.00001387336,0.0004381657,0.0002391227,0.0001172838,0.00001931442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001236103,0.00002524182,0.00240157,0.00004278277,0.00002442848,1.428352e-7,0.00001653666,0.00008909631,0.9970169,0.000140554,0.00001367722,0.0001054805],"study_design_scores_gemma":[0.000481837,0.0002935625,0.001693911,0.00002815173,0.00002867982,0.000001751649,0.00002864353,0.0005616307,0.9964207,0.0002987189,0.00006559299,0.00009676492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969288,0.0001254207,0.002169962,0.0001520171,0.0000362863,0.000530552,0.00001630632,0.000002886156,0.00003781641],"genre_scores_gemma":[0.9984832,0.00000279813,0.0009382215,0.00001340535,0.00001377718,0.0000118839,0.00006341891,0.00001426444,0.0004590537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001554424,"threshold_uncertainty_score":0.3324928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00228079605081479,"score_gpt":0.1993735507288799,"score_spread":0.1970927546780651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}