{"id":"W2108098608","doi":"10.1016/j.jconrel.2013.07.032","title":"Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke","year":2013,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Stem Cell Network; Ontario Neurotrauma Foundation; Heart and Stroke Foundation of Canada","keywords":"PLGA; Erythropoietin; Epidermal growth factor; Growth factor; Regeneration (biology); Chemistry; Biomedical engineering; Neural stem cell; Glycolic acid; Regenerative medicine; Cell biology; Pharmacology; Medicine; Stem cell; Lactic acid; Biochemistry; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678781,0.0005263572,0.0004074201,0.0003790437,0.0001094139,0.0004081595,0.0002400732,0.0004179908,0.001177591],"category_scores_gemma":[0.0001716976,0.0001976526,0.0003108899,0.0002170735,0.0002680268,0.0004721156,0.0002074995,0.0004448612,0.000296349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003006702,"about_ca_system_score_gemma":0.0003476314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001160087,"about_ca_topic_score_gemma":0.003261391,"domain_scores_codex":[0.9998753,0.00001115221,0.00001096337,0.00003600859,0.00002730732,0.00003930322],"domain_scores_gemma":[0.9999226,0.00001912405,0.00002569324,0.000007441256,0.000007913127,0.00001717708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005143785,0.0001126458,0.00005991581,0.00007823554,0.00001202712,0.00005266435,0.00002142131,0.0002935603,0.9903625,0.0001044585,0.00008101244,0.00830722],"study_design_scores_gemma":[0.00009399059,0.0009969057,0.000932471,0.000008447028,0.00005712953,0.0001354412,0.00001320309,0.001722188,0.9949356,0.00006250843,0.001032318,0.000009757954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887902,0.002825808,0.006791841,0.00005180432,0.0001000989,0.00005591722,0.0001289839,0.0001093708,0.001146112],"genre_scores_gemma":[0.9911088,0.001417418,0.004764088,0.00003220449,0.00004130673,0.00006104413,0.00009901675,0.00002561669,0.002450477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177591,"threshold_uncertainty_score":0.00393939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317340892630554,"score_gpt":0.2519352974903489,"score_spread":0.2387618885640434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}