{"id":"W2108102133","doi":"10.1016/j.ymgme.2014.04.007","title":"Pleiotropic genes for metabolic syndrome and inflammation","year":2014,"lang":"en","type":"review","venue":"Molecular Genetics and Metabolism","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; Medical Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Nursing Research; Johns Hopkins University; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Center for Advancing Translational Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Pleiotropy; Genome-wide association study; Metabolic syndrome; Single-nucleotide polymorphism; SNP; Biology; Genetics; Quantitative trait locus; Genetic association; Diabetes mellitus; Gene; Bioinformatics; Genotype; Endocrinology; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001790642,0.001129199,0.0009783617,0.00160223,0.0004116867,0.0007913256,0.0004481607,0.0004997056,0.00544906],"category_scores_gemma":[0.004294226,0.0003178395,0.002287021,0.002479257,0.0004545219,0.0003301392,0.001019511,0.0008587861,0.0003588615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003006381,"about_ca_system_score_gemma":0.0007397298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001584033,"about_ca_topic_score_gemma":0.001847218,"domain_scores_codex":[0.9985873,0.0007102631,0.0001170685,0.0003375239,0.0001789266,0.00006902408],"domain_scores_gemma":[0.9978876,0.001037347,0.0005931141,0.000228905,0.0001195558,0.0001334977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004560957,0.0001719454,0.8556315,0.002306463,0.01167501,0.003098805,0.0004430277,0.005431623,0.02752473,0.007866007,0.003938831,0.07735117],"study_design_scores_gemma":[0.0004566988,0.0003646481,0.9603584,0.0003405045,0.005077546,0.003535103,0.0001997798,0.006895381,0.002799937,0.01102411,0.008857509,0.00009043171],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8506221,0.06886117,0.05911581,0.002417449,0.0005520771,0.000283339,0.01125166,0.0008360881,0.006060401],"genre_scores_gemma":[0.9722742,0.006804885,0.01650361,0.0002576681,0.0002028346,0.0002000841,0.002911121,0.0000527613,0.0007927546],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00544906,"threshold_uncertainty_score":0.01822889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309123917386927,"score_gpt":0.2771736369290204,"score_spread":0.2640823977551511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}