{"id":"W2108141823","doi":"10.1172/jci21838","title":"High-level β-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Heart, Lung, and Blood Institute; Genentech; National Institutes of Health; Stem Cell Network","keywords":"Biology; Haematopoiesis; Cord blood; Transgene; Stem cell; Viral vector; Transduction (biophysics); Molecular biology; Genetic enhancement; Progenitor cell; Globin; Transplantation; CD34; Myeloid; Gene; Virology; Cancer research; Immunology; Cell biology; Genetics; Recombinant DNA; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00110601,0.0001204597,0.0002694354,0.00008181303,0.00004201865,0.00002194427,0.0001241662,0.000222447,0.00001377526],"category_scores_gemma":[0.00007560311,0.0001002452,0.0001484601,0.00008390228,0.0002261169,0.00003255518,0.00002628982,0.0002855671,0.000001051034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001492669,"about_ca_system_score_gemma":0.0001571767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000102593,"about_ca_topic_score_gemma":0.00006010131,"domain_scores_codex":[0.9980819,0.000314653,0.001007564,0.0001980818,0.0002770532,0.0001207818],"domain_scores_gemma":[0.9988311,0.00002932534,0.0005800892,0.0001691928,0.0002576669,0.0001326305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002373591,0.000162199,0.001138842,0.00002301871,0.00006211857,0.00000245701,0.0000837628,0.0001202633,0.9878944,0.00002014902,0.00005646481,0.008062756],"study_design_scores_gemma":[0.002552478,0.007316211,0.008472279,0.0001284824,0.00006172116,0.00001332237,0.00004790387,0.000009005816,0.9799238,0.001363048,0.00001885797,0.00009292123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971768,0.0002808878,0.001937782,0.0001809388,0.0002449593,0.0001589629,0.00001051103,0.000003351876,0.000005780019],"genre_scores_gemma":[0.9973238,0.0003051845,0.001815845,0.00007333546,0.0003925388,0.000005035189,0.00002015432,0.0000131518,0.00005091824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007970609,"threshold_uncertainty_score":0.408788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08391455691124541,"score_gpt":0.3641750566706373,"score_spread":0.2802604997593918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}