{"id":"W2108152062","doi":"10.1016/j.clbc.2015.09.006","title":"A Uridine Glucuronosyltransferase 2B7 Polymorphism Predicts Epirubicin Clearance and Outcomes in Early-Stage Breast Cancer","year":2015,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa; University of Alberta","funders":"Indiana Clinical and Translational Sciences Institute; National Institutes of Health; Alberta Cancer Foundation; Pfizer","keywords":"Epirubicin; Medicine; Internal medicine; Gastroenterology; Breast cancer; Toxicity; Single-nucleotide polymorphism; Oncology; Genotype; Endocrinology; Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006541036,0.0003260554,0.0009263861,0.0001147589,0.00005254723,0.00003194495,0.0001314363,0.0003262473,0.0002511131],"category_scores_gemma":[0.0001020278,0.0002802466,0.0002278726,0.0003028156,0.0003319424,0.000237369,0.0000442161,0.0006636599,0.0000231488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000260332,"about_ca_system_score_gemma":0.0005403449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00372006,"about_ca_topic_score_gemma":0.0008879185,"domain_scores_codex":[0.9975163,0.0001452875,0.0007633336,0.0006653318,0.0004269437,0.000482748],"domain_scores_gemma":[0.9984092,0.0001622051,0.0001353001,0.0004111928,0.0001776385,0.0007044989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002646795,0.0004060184,0.9453489,0.00008867298,0.0001896984,0.00008148629,0.0004329838,0.00003097617,0.003617246,0.00005665273,0.0005438199,0.04655677],"study_design_scores_gemma":[0.01017252,0.0002029653,0.9841823,0.0004669084,0.0001326624,0.0001513779,0.00007483121,0.0002165024,0.002424478,0.00005765514,0.001618579,0.0002992211],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763123,0.001116975,0.00005126238,0.02025109,0.0006002216,0.0006459751,0.000647752,0.0000967978,0.0002775718],"genre_scores_gemma":[0.9916636,0.00155142,0.00005895907,0.004727452,0.00098374,0.0001167388,0.00001609341,0.00005925031,0.0008227511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04625755,"threshold_uncertainty_score":0.999965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04657264548811241,"score_gpt":0.3573558239700384,"score_spread":0.310783178481926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}