{"id":"W2108193414","doi":"10.1261/rna.2040410","title":"Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein","year":2010,"lang":"en","type":"article","venue":"RNA","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of General Medical Sciences; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canton de Genève; Fondation Medic; Welch Foundation; National Institutes of Health; National Science Foundation","keywords":"Signal recognition particle; Biology; Ribonucleoprotein; Signal recognition particle receptor; Cell biology; Ribosome; Endoplasmic reticulum; Cytoplasm; Biochemistry; Translocon; Translation (biology); RNA; Biophysics; Chromosomal translocation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436659,0.0004667415,0.0003324106,0.0001285267,0.0001482814,0.0001811276,0.0002141632,0.0002761503,0.0007987093],"category_scores_gemma":[0.0001681806,0.0001625196,0.0003126462,0.0001122368,0.0003686726,0.000149389,0.000248087,0.0003095259,0.0007055273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002715424,"about_ca_system_score_gemma":0.0002446227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000434863,"about_ca_topic_score_gemma":0.0004478076,"domain_scores_codex":[0.9998959,0.00002211109,0.00001513331,0.00002229954,0.00002569162,0.00001874253],"domain_scores_gemma":[0.9997714,0.00004014919,0.00008167073,0.00002285824,0.00002459376,0.00005940069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002974693,0.00002940849,0.0006777894,0.00004251807,0.00001210931,0.0003310002,0.00001209533,0.0002007715,0.9968197,0.0001218404,0.00002311043,0.001432173],"study_design_scores_gemma":[0.00006943023,0.0005454472,0.01803651,0.00001380617,0.00004104612,0.001542579,0.00003399852,0.001603922,0.976383,0.0001568945,0.001560527,0.00001278558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958538,0.0003820145,0.002845953,0.00004611427,0.00001687006,0.00003180824,0.0001812051,0.00004284665,0.0005994607],"genre_scores_gemma":[0.9958702,0.0001546493,0.003130297,0.00003672072,0.000007985996,0.0000160522,0.0003181039,0.00001698193,0.0004490729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007987093,"threshold_uncertainty_score":0.002671897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113506895414378,"score_gpt":0.2248779819831211,"score_spread":0.2135272924416833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}