{"id":"W2108194569","doi":"10.1021/ol3027939","title":"A Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors","year":2012,"lang":"en","type":"article","venue":"Organic Letters","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"University of Victoria; Canadian Institutes of Health Research; British Columbia Centre for Disease Control; Genome British Columbia; University of Notre Dame","keywords":"Neuraminidase; Bicyclic molecule; Mutation; Hemagglutinin (influenza); Chemistry; Virology; Neuraminidase inhibitor; Virus; Computational biology; Stereochemistry; Gene; Biology; Biochemistry; Coronavirus disease 2019 (COVID-19); Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781975,0.000436609,0.0002353857,0.0003135136,0.0002374176,0.0002874589,0.0005551383,0.0004019827,0.002256269],"category_scores_gemma":[0.0002031481,0.0001777346,0.0001771001,0.000221117,0.000231453,0.0003687434,0.0005155479,0.0006777546,0.0008839407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003103882,"about_ca_system_score_gemma":0.0002680825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000471207,"about_ca_topic_score_gemma":0.0009483742,"domain_scores_codex":[0.9998875,0.00001534865,0.000008646748,0.00002067528,0.00003628134,0.00003152244],"domain_scores_gemma":[0.9999437,0.000007256337,0.00001716195,0.000008949389,0.000007681122,0.00001530866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005645491,0.0001353744,0.00008463776,0.0004880573,0.00002153724,0.0005266539,0.0001398782,0.003491664,0.9350803,0.02001887,0.002670042,0.03677845],"study_design_scores_gemma":[0.0003784348,0.005493477,0.0006680787,0.00009178949,0.00004767333,0.0008982988,0.00006721896,0.01002137,0.9054157,0.003295751,0.07348503,0.000137247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7945525,0.01832175,0.111852,0.002047742,0.001286704,0.0007709924,0.001992574,0.001144494,0.06803121],"genre_scores_gemma":[0.945738,0.006447354,0.03549017,0.0004877436,0.0000724005,0.0002286837,0.0005439585,0.00005608315,0.01093561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002256269,"threshold_uncertainty_score":0.007547975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08919639856293174,"score_gpt":0.3328797141494316,"score_spread":0.2436833155864999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}