{"id":"W2108213063","doi":"10.1021/bi0346648","title":"Mechanism of Proton Transfer Inhibition by Cd<sup>2+</sup>Binding to Bacterial Reaction Centers:  Determination of the p<i>K</i><sub>A</sub>of Functionally Important Histidine Residues","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences","keywords":"Rhodobacter sphaeroides; Chemistry; Histidine; Proton; Photosynthetic reaction centre; Imidazole; Electron transfer; Dissociation constant; Binding site; Stereochemistry; Mutant; Quinone; Binding energy; Crystallography; Photochemistry; Photosynthesis; Biochemistry; Enzyme; Atomic physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214975,0.000391185,0.0003437436,0.0000894768,0.000150289,0.0004256208,0.0005390483,0.0005274671,0.0007728224],"category_scores_gemma":[0.0003779174,0.0002392149,0.0001981559,0.00007701865,0.0004435669,0.0003189149,0.0002230367,0.0005449654,0.0003508876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007512154,"about_ca_system_score_gemma":0.0001921436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008339039,"about_ca_topic_score_gemma":0.0004454067,"domain_scores_codex":[0.9998141,0.00003926515,0.00001236861,0.00004057854,0.00005792497,0.00003577445],"domain_scores_gemma":[0.9997953,0.00007332481,0.00004858835,0.00001437128,0.00004220394,0.00002619168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005035112,0.00006562656,0.001144782,0.0001141932,0.00001555733,0.00006381591,0.00002617656,0.0008352713,0.9952238,0.0001592466,0.0001036398,0.00174443],"study_design_scores_gemma":[0.00003824384,0.000178584,0.006370909,0.000005946474,0.00001014681,0.0001514931,0.00002051893,0.007387416,0.9851285,0.00007774782,0.0006184558,0.00001207556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927346,0.001405049,0.00400715,0.0002066177,0.00002079159,0.00004264846,0.0002206144,0.0001290576,0.001233512],"genre_scores_gemma":[0.9979841,0.0003221605,0.001076099,0.0000545165,0.00000378369,0.00001664728,0.0001201231,0.000007051633,0.0004154998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008339039,"threshold_uncertainty_score":0.005450428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005762801884347495,"score_gpt":0.2006815528348845,"score_spread":0.194918750950537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}