{"id":"W2108213063","doi":"10.1021/bi0346648","title":"Mechanism of Proton Transfer Inhibition by Cd<sup>2+</sup>Binding to Bacterial Reaction Centers:  Determination of the p<i>K</i><sub>A</sub>of Functionally Important Histidine Residues","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences","keywords":"Rhodobacter sphaeroides; Chemistry; Histidine; Proton; Photosynthetic reaction centre; Imidazole; Electron transfer; Dissociation constant; Binding site; Stereochemistry; Mutant; Quinone; Binding energy; Crystallography; Photochemistry; Photosynthesis; Biochemistry; Enzyme; Atomic physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002570031,0.0001752777,0.0001916698,0.00003489815,0.00004876852,0.000006620332,0.0001252955,0.0002125708,0.00001241188],"category_scores_gemma":[0.0001677831,0.0001546767,0.0001304259,0.0001193241,0.00005280813,0.000008638612,0.00003847222,0.00006935673,4.167687e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003873055,"about_ca_system_score_gemma":0.0001461206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007971429,"about_ca_topic_score_gemma":0.000003097124,"domain_scores_codex":[0.9987586,0.00003998943,0.0004642102,0.0003196571,0.00024553,0.0001720651],"domain_scores_gemma":[0.9992236,0.000009250453,0.0002248618,0.0002955422,0.0001840293,0.00006269407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000235058,0.0001358373,0.00003992447,0.0002485777,0.00002178406,3.72841e-7,0.00003767767,0.000001541982,0.9989455,0.00009920476,0.00006714643,0.000167405],"study_design_scores_gemma":[0.000504045,0.0002447737,0.00001220715,0.0001501376,0.00004127494,0.00001959987,0.00008401465,0.00001240412,0.9981476,0.000165399,0.0004680374,0.0001505069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99504,0.00004831939,0.003939396,0.00003491292,0.0001161931,0.0004359188,0.0002366838,0.000007230878,0.0001413749],"genre_scores_gemma":[0.9992706,0.00008047326,0.0001931401,0.0000276203,0.00005873823,0.00007125637,0.0002180544,0.00002160369,0.00005852775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004230615,"threshold_uncertainty_score":0.6307531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005762801884347495,"score_gpt":0.2006815528348845,"score_spread":0.194918750950537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}