{"id":"W2108226120","doi":"10.1371/journal.ppat.0030035","title":"Dynorphin Activates Quorum Sensing Quinolone Signaling in Pseudomonas aeruginosa","year":2007,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Pyocyanin; Virulence; Pseudomonas aeruginosa; Quorum sensing; Dynorphin; Microbiology; Caenorhabditis elegans; Signal transduction; Chemistry; Biology; Cell biology; Opioid; Bacteria; Receptor; Biochemistry; Opioid peptide; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003813864,0.0002458691,0.0002455841,0.0001229108,0.0001099543,0.00003818827,0.0001143637,0.0002701756,0.00001511825],"category_scores_gemma":[0.0001171329,0.0002504779,0.0001043599,0.0001909287,0.00007121047,0.000007617495,0.0001162948,0.0001753717,0.00002129997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003512637,"about_ca_system_score_gemma":0.00004552901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005840835,"about_ca_topic_score_gemma":0.0001947094,"domain_scores_codex":[0.9982983,0.00006692115,0.0003586348,0.000481491,0.000154726,0.0006398601],"domain_scores_gemma":[0.9993293,0.00003592146,0.0001135247,0.0003293294,0.00006934877,0.0001225514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001371221,0.00007710364,0.005485531,0.00001375397,0.00003342002,0.00009664962,0.0001055942,0.00001468252,0.9897013,0.00002423749,0.00003887289,0.004271715],"study_design_scores_gemma":[0.0004389968,0.0001183781,0.005874554,0.00005978922,0.00001781806,0.0000462121,0.0002021402,0.00004919229,0.9916107,0.00002107096,0.001230385,0.0003307383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983585,0.0002078995,0.0002414499,0.0001851887,0.0002311987,0.0001748943,0.00002129848,0.00003589255,0.0005436738],"genre_scores_gemma":[0.9940711,0.00004774598,0.0048985,0.0002726065,0.0004804521,0.000001170262,0.0001035579,0.00004368717,0.00008116636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004657051,"threshold_uncertainty_score":0.9999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01384032256680844,"score_gpt":0.2326308991949804,"score_spread":0.218790576628172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}