{"id":"W2108248587","doi":"10.1634/theoncologist.2013-0427","title":"Discordance in Hormone Receptor Status Among Primary, Metastatic, and Second Primary Breast Cancers: Biological Difference or Misclassification?","year":2014,"lang":"en","type":"review","venue":"The Oncologist","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Saskatchewan","funders":"National Center for Advancing Translational Sciences; Fogarty International Center; American Cancer Society","keywords":"Medicine; Breast cancer; Estrogen receptor; Oncology; Internal medicine; Hormone receptor; Progesterone receptor; Receptor; Primary tumor; Epidemiology; Cancer; Gynecology; Hormone; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003627953,0.0006027764,0.001557994,0.00005576129,0.0001669794,0.00005385016,0.000502128,0.0002802345,0.00003815515],"category_scores_gemma":[0.000113711,0.0003151624,0.0001797558,0.0001979408,0.001273503,0.000006486001,0.0004535691,0.0003512175,0.00001234689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006137465,"about_ca_system_score_gemma":0.000687225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002624467,"about_ca_topic_score_gemma":0.00176041,"domain_scores_codex":[0.9972577,0.0005512527,0.0006228617,0.0008793779,0.0001538047,0.000534973],"domain_scores_gemma":[0.9982523,0.0003350864,0.0005700146,0.0006727998,0.00005234272,0.0001174452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005746496,0.0003341736,0.003310451,0.003047092,0.0007509746,0.00001829186,0.0001085726,9.991171e-7,0.0003050123,0.00007516106,0.004442857,0.9870318],"study_design_scores_gemma":[0.0010512,0.00054443,0.1094396,0.000973404,0.0004046788,0.0001063344,0.0001096171,9.756495e-7,0.000007869276,0.00002634715,0.8866962,0.0006393833],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006961675,0.9897585,0.00005687261,0.0001792994,0.0001660717,0.001148992,0.000968334,0.00002387997,0.0007363719],"genre_scores_gemma":[0.003858877,0.9920266,0.0004873774,0.0001803445,0.0002492177,0.001058832,0.001156667,0.00004536531,0.0009367583],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9863924,"threshold_uncertainty_score":0.99993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05005637811176843,"score_gpt":0.3266275127155266,"score_spread":0.2765711346037582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}