{"id":"W2108267527","doi":"10.1002/ejp.798","title":"A novel orally administered trimebutine compound (<scp>GIC</scp>‐1001) is anti‐nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide‐releasing capacity in mice","year":2015,"lang":"en","type":"article","venue":"European Journal of Pain","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Inversago Pharma (Canada)","funders":"","keywords":"Nociception; Pharmacology; Opioid; Chemistry; Medicine; Anesthesia; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002411562,0.0002578465,0.0005345249,0.0001582176,0.00009175592,0.00008999484,0.0001256236,0.00004377425,0.000005304033],"category_scores_gemma":[0.003148867,0.0002254766,0.00009423911,0.0001777716,0.0002893797,0.0001950944,0.00007545493,0.0006518346,0.000002791651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009200344,"about_ca_system_score_gemma":0.0001791272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001146052,"about_ca_topic_score_gemma":0.00003946469,"domain_scores_codex":[0.9976768,0.0009300825,0.0004750462,0.0002759877,0.0003162411,0.0003258041],"domain_scores_gemma":[0.9983798,0.0003694382,0.0003885795,0.0001399069,0.0002383554,0.0004839816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006026733,0.003368362,0.4282838,0.001034027,0.0005753844,0.006563899,0.0442955,0.0001316443,0.4752586,0.00006326391,0.006015444,0.02838328],"study_design_scores_gemma":[0.00909966,0.003619582,0.9708753,0.0007983435,0.0001627164,0.00643111,0.005115379,0.0008709152,0.001141739,0.00009149557,0.001630591,0.0001631392],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953144,0.0006699511,0.001751748,0.0009755349,0.00005674917,0.0001982701,0.00001667456,0.00001641145,0.001000292],"genre_scores_gemma":[0.9927983,0.00002605831,0.006194545,0.0005974623,0.0001462955,3.93245e-7,0.000003604489,0.00003198219,0.0002013959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5425915,"threshold_uncertainty_score":0.9194669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05450966527890172,"score_gpt":0.2659981891532143,"score_spread":0.2114885238743126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}