{"id":"W2108268005","doi":"10.3747/co.19.866","title":"Phase I Study of the Plk1 Inhibitor BI 2536 Administered Intravenously on Three Consecutive Days in Advanced Solid Tumours","year":2012,"lang":"en","type":"article","venue":"Current Oncology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Pharmacokinetics; Leukopenia; Nausea; Adverse effect; Dysgeusia; Anorexia; Toxicity; Pharmacology; Response Evaluation Criteria in Solid Tumors; Constipation; Population; Vomiting; Internal medicine; Neutropenia; Gastroenterology; Phases of clinical research","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002154051,0.0001940434,0.0003090056,0.00006438843,0.00005779822,0.00000477095,0.0002766903,0.0001530542,0.000009825131],"category_scores_gemma":[0.0001053612,0.0001514545,0.00008415394,0.0001145668,0.0001427976,0.000004700121,0.0001983798,0.00024564,0.000005996543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007040959,"about_ca_system_score_gemma":0.0001791118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001037511,"about_ca_topic_score_gemma":0.0005236097,"domain_scores_codex":[0.9986437,0.0002053132,0.0003718394,0.0002982588,0.0001093542,0.0003715254],"domain_scores_gemma":[0.9991711,0.00003959643,0.0002253675,0.0004067783,0.00006968279,0.00008750249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002584506,0.04523168,0.1438325,0.00008089637,0.0001774949,0.00001192017,0.005785368,0.00005988234,0.7364699,0.0003443618,0.002046886,0.06337459],"study_design_scores_gemma":[0.04082029,0.04642238,0.07742704,0.0002758498,0.0003003458,0.00009117898,0.009978988,0.0001766866,0.7319779,0.0001592932,0.09110396,0.001266042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964435,0.000695086,0.00006766359,0.00006774881,0.001469444,0.0008309453,0.00005084528,0.000005947689,0.0003687863],"genre_scores_gemma":[0.9993678,0.00008039352,0.00002833184,0.00009794195,0.0002513122,0.00008629181,0.0000459167,0.00001911945,0.00002294834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08905707,"threshold_uncertainty_score":0.6176136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04939373050524702,"score_gpt":0.3794436418418313,"score_spread":0.3300499113365842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}